Figure 6

Phylogenetic conservation of WW domains among yeast lineages. Radial trees were generated based upon multiple alignments for orthologs culled from 24 yeast species. Solid lines indicate lineages in which the WW domain is maintained in the orthologous proteins, whereas dashed lines indicate those proteins in which the WW domain is not present. In the Set2 ortholog group, the WW domains highlighted in gray are most similar to the meta-WW domain in S. cerevisiae, whereas in the other lineages the WW domain conforms to the group II/III classification. Organism abbreviations are Saccharomyces cerevisiae (Sc),Candida guilliermondii (Cgui),Candida glabrata (Cgla),Chaetomium globosum (Cglo),Kluyveromyces waltii (Kw),Kluyveromyces lactis (Kl),Yarrowia lipolytica (Yl),Candida lusitaniae (Cl),Debaryomyces hansenii (Dh),Schizosaccharomyces pombe (Sp),Pneumocystis carinii (Pc),Fusarium graminearum (Fg),Magnaporthe grisea (Mg),Neurospora crassa (Nc),Podospora anserina (Pa),Aspergillus fumigatus (Af),Aspergillus nidulans (An),Ashbya gosypii (Ag),Histoplasma capsulatum (Hc),Coccidioides immitis (Ci), Ustilago maydis (Um),Cryptococcus neoformans (Cn),Coprinus cinereus (Cc),and Rhizopus oryzae (Ro).