Table 1 Top 50 genes predicted by hidden variable dynamic modeling to be p53 regulated, ranked by sensitivity Z score
From: Ranked prediction of p53 targets using hidden variable dynamic modeling
Gene title | Gene symbol | Affymetrix identifier | Model score (M) | Sensitivity (Z score) | RNAi validation score |
|---|---|---|---|---|---|
Damage-specific DNA binding protein 2, 48 kDa | DDB2 | 203409_at | 18.74 | 18.24 | 10.74 |
CD38 antigen (p45) | CD38 | 205692_s_at | 36.69 | 14.77 | 9.02 |
Ferredoxin reductase | FDXR | 207813_s_at | 79.82 | 13.19 | 7.72 |
Hypothetical protein FLJ22457 | FLJ22457 | 221081_s_at | 60.45 | 11.01 | 6.33 |
Tripartite motif-containing 22 | TRIM22 | 213293_s_at | 41.36 | 10.99 | 6.07 |
Carnitine O-octanoyltransferase | CROT | 204573_at | 84.40 | 10.98 | 3.80 |
Glutaminase 2 (liver, mitochondrial) | GLS2 | 205531_s_at | 42.83 | 10.28 | 2.52 |
Leucine-rich repeats and death domain containing | LRDD | 219019_at | 78.80 | 9.90 | 3.09 |
Hect domain and RLD 5 | HERC5 | 219863_at | 37.65 | 9.55 | 1.91 |
Cyclin G 1 | CCNG1 | 208796_s_at | 17.04 | 9.37 | 5.18 |
BCL2-interacting killer | BIK | 205780_at | 19.43 | 9.35 | 6.57 |
Activating signal cointegrator 1 complex subunit 3 | ASCC3 | 212815_at | 60.34 | 9.26 | 5.93 |
Sestrin 1 | SESN1 | 218346_s_at | 8.37 | 9.25 | 3.90 |
p53 target zinc finger protein | WIG1 | 219628_at | 41.33 | 9.19 | 3.70 |
Tumor necrosis factor receptor superfamily, member 10b | TNFRSF10B | 209295_at | 27.34 | 9.05 | 6.52 |
Chromosome 6 open reading frame 4 | C6orf4 | 215411_s_at | 86.45 | 8.81 | 6.64 |
Cyclin-dependent kinase inhibitor 1A(p21) | CDKN1A | 202284_s_at | 24.98 | 8.40 | 8.07 |
Etoposide induced 2.4 mRNA | EI24/PIG8 | 216396_s_at | 88.04 | 8.20 | 4.09 |
Mitogen-activated protein kinase kinase kinase kinase 4 | MAP4K4 | 206571_s_at | 62.88 | 7.54 | 1.88 |
Lymphoid-restricted membrane protein | LRMP | 204674_at | 26.92 | 7.36 | 3.40 |
Xeroderma pigmentosum, group C | XPC | 209375_at | 43.09 | 7.36 | 5.80 |
TNF (ligand) superfamily, member 4 (Ox40L) | TNFSF4 | 207426_s_at | 34.73 | 7.15 | 5.26 |
Human cleavage/polyadenylation specificity factor | CPSF1 | 33132_at | 77.75 | 7.09 | -1.44 |
AMP-activated protein kinase, beta 1 subunit | PRKAB1 | 201834_at | 25.72 | 7.01 | 6.30 |
Transducer of ERBB2, 1 | TOB1 | 202704_at | 92.69 | 6.79 | 5.78 |
p53-inducible cell-survival factor | P53CSV | 218403_at | 48.33 | 6.50 | 7.75 |
Sortilin-related receptor, L(DLR class) | SORL1 | 203509_at | 15.66 | 6.34 | 1.70 |
Fas (TNF receptor superfamily, member 6) | FAS | 216252_x_at | 44.31 | 6.23 | 4.54 |
Ribonucleotide reductase M1 polypeptide | RRM1 | 201477_s_at | 46.58 | 6.19 | 0.41 |
Archaemetzincins-2 | AMZ2 | 218167_at | 37.48 | 6.16 | 1.22 |
Galactose-3-O-sulfotransferase 4 | GAL3ST4 | 219815_at | 38.62 | 5.97 | 3.12 |
Growth arrest and DNA-damage-inducible, alpha | GADD45A | 203725_at | 84.23 | 5.89 | 11.05 |
Hypothetical protein FLJ11259 | FLJ11259 | 218627_at | 7.23 | 5.87 | 3.56 |
Major histocompatibility complex, class I, B | HLA-B | 209140_x_at | 89.77 | 5.79 | 0.63 |
Testis specific, 10 | TSGA10 | 220623_s_at | 20.85 | 5.67 | 0.47 |
Hypothetical protein MDS025 | MDS025 | 218288_s_at | 31.35 | 5.66 | 2.38 |
TP53 activated protein 1 | TP53AP1 | 209917_s_at | 22.22 | 5.65 | 4.05 |
Leukemia inhibitory factor | LIF | 205266_at | 14.86 | 5.62 | 3.42 |
Interferon stimulated exonuclease gene 20 kDa-like 1 | ISG20L1 | 219361_s_at | 48.55 | 5.56 | 5.43 |
Lymphoid-restricted membrane protein | LRMP | 35974_at | 42.06 | 5.56 | 3.69 |
Integral membrane protein 2B | ITM2B | 217732_s_at | 20.25 | 5.52 | -0.19 |
Tumor necrosis factor receptor superfamily, member 10b | TNFRSF10B | 210405_x_at | 46.05 | 5.52 | 1.69 |
REV3-like, catalytic subunit DNA polymerase zeta | REV3L | 208070_s_at | 65.17 | 5.45 | 6.73 |
TP53 activated protein 1 | TP53AP1 | 210886_x_at | 30.15 | 5.42 | 2.88 |
Leucine-rich repeats and death domain containing | LRDD | 221640_s_at | 55.27 | 5.31 | 1.54 |
AMP-activated protein kinase, beta 1 | PRKAB1 | 201835_s_at | 25.45 | 5.27 | 5.92 |
Nonmetastatic cells 1 (NM23A) | NME1 | 201577_at | 83.39 | 5.15 | 3.38 |
Tubulin, gamma 1 | TUBG1 | 201714_at | 41.74 | 5.09 | 0.02 |
Solute carrier family 7, member 6 | SLC7A6 | 203579_s_at | 18.59 | 4.98 | 2.56 |
RAD51 homolog | RAD51C | 209849_s_at | 21.02 | 4.92 | 1.11 |