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Figure 2 | Genome Biology

Figure 2

From: Ranked prediction of p53 targets using hidden variable dynamic modeling

Figure 2

Parameter estimation for a training set of five known p53 targets. (a) The model equation was solved to estimate values for the parameters basal transcription Bj sensitivity Sj, and degradation Dj for the five p53 targets DDB2, p21WAF1/CIP1, SESN1/hPA26, BIK, and TNFRSF10b/TRAILreceptor 2. (b) Simultaneously, the activity profile f(t) of p53 was derived from three separate microarray time courses.

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