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Figure 3 | Genome Biology

Figure 3

From: Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins

Figure 3

Fungal kinetochores contain a set of point centromere specific components. Schematic model of kinetochore subunitorganization based on the architecture of the S. cerevisiae kinetochore. Kinetochore proteins can be roughly divided into DNA-binding (pink), linker (blue), MT-binding (green) and regulatory layers (yellow). Within each layer many proteins are organized into multi-protein complexes, for example, the linker layer is composed of at least four complexes (gray boxes (a) to (d)): COMA, NDC80, MIND and SPC105. Protein names are given for S. cervisiae first and S. pombe second, while essential genes (italic letters) and non-essential (normal letters) is indicated. Protein names followed by an asterisk indicate that this specific ortholog is known not to localize to kinetochores. The kinesins present at kinetochores in S. cerevisiae are Kip3 (Kinesin-8), Cin8 (Kinesin-5), Kip1 (Kinesin-5) and Kar3 (Kinesin-14), while in S. pombe they are Klp5 (Kinesin-8), Klp6 (Kinesin-8) and Klp2 (Kinesin-14) (for nomenclature see [38].

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