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Figure 3 | Genome Biology

Figure 3

From: Modulation of the transcription regulatory program in yeast cells committed to sporulation

Figure 3

Transcriptional response of return to growth (RTG) cells. SPM, sporulation medium; YPD, growth medium. (a) The expression pattern of early sporulation (spo) genes (61 early I genes, as defined in [7]). Note the immediate repression of these genes upon transfer to growth medium (see Additional data file 3 for early genes defined according to the data presented in the current study; see Additional data file 5 for a matlab program that enables the reader to view the data in that format). (b) Expression pattern of IME1, the regulator of early-sporulation genes. (c) Expression pattern of the G1 cyclin gene, CLN3. In (a-c), expression patterns are shown as log2 ratios, and are color-coded for the log2 fold change according to the bar shown. (d) Polarized expression of genes associated with DNA repair and DNA recombination. The matrix of pairwise correlations between genes assigned to the GO groups 'DNA recombination' and 'DNA repair' is plotted. The genes were clustered according to similarity in their Pearson correlations, calculated on the basis of their expression patterns in our experiment (see Materials and methods). The average expression pattern of genes in each cluster is shown on the right. The first cluster include genes expressed during early sporulation, the second includes genes induced during middle sporulation, the third shows genes induced during RTG, and the fourth genes that are transiently induced on transfer to YPD and then repressed. The number of genes in each cluster is indicated above the arrow. Some of the genes in each cluster are indicated (for a full list of genes, and for a similar representation of additional gene classes, see Additional data files 22 and 33). Correlations are color-coded according to the bar shown.

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