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Table 1 Selection of 30 genes considered for further Q-PCR analysis

From: Deciphering cellular states of innate tumor drug responses

 

Symbol

Clone ID

M

T

T&M

All tumor samples (T&M)

      

Intensity

Ratio

Min-value

Max P value

1

ABCA2

3508171

0

0

1

411

-1.4

4.36E-05

4.93E-05

2

ABL1

345666

1

0

0

569

-1.5

1.44E-04

1.44E-04

3

CASP1

486506

0

1

0

714

1.9

6.30E-06

6.93E-06

4

CHEK1

3530606

1

0

1

1,901

1.6

1.66E-05

3.89E-05

5

CHEK2

3532866

0

0

1

2,624

1.4

2.72E-05

3.77E-05

6

COL4A2

3507072

0

0

1

5,813

-1.6

7.86E-03

7.86E-03

7

COL6A1

3506644

1

1

1

4,268

-2.6

4.43E-12

3.63E-02

8

COL6A2

3347413

1

0

1

3,906

-4.3

1.37E-11

1.31E-02

9

FOS

3688670

1

0

1

8,312

-1.7

7.39E-05

1.28E-04

10

HRASLS3

3051149

0

1

0

1,814

-1.7

6.22E-05

6.22E-05

11

LAMB1

428443

1

0

1

2,747

-1.5

5.06E-06

2.93E-04

12

MAD2L1

2964388

1

0

1

4,141

1.6

2.94E-05

1.99E-04

12

MMP11

725180

1

0

1

2,917

-2.3

1.78E-05

3.42E-02

14

PEA15

3346270

0

0

1

1,366

-1.3

3.48E-04

3.48E-04

15

RAD51

3139011

1

0

0

1,630

1.9

9.78E-03

9.78E-03

16

RECQL4

3634266

1

0

1

3,372

1.6

9.13E-06

1.76E-05

17

RERG

3357341

1

1

1

294

-3.6

1.17E-05

3.63E-02

18

RRAGD

3536088

1

0

1

596

-2.6

6.70E-07

4.35E-02

19

SERPINF1

2961120

1

0

1

1,902

-1.5

8.33E-10

2.74E-05

20

TGFBI

2958878

1

1

1

13,900

-2.4

5.43E-10

1.31E-02

21

TOP2B

470615

1

0

1

495

1.5

6.15E-06

2.34E-04

22

TP53

3544714

1

0

1

4,178

1.8

1.06E-06

1.32E-05

23

BCL2

232714

0

0

0

787

 

Not significant

 

24

CES2

4298532

0

0

0

6,538

 

Not significant

 

25

E2F4

3504728

0

0

0

5,620

 

Not significant

 

26

ITGB6

759142

0

0

0

648

 

Not significant

 

27

JUN

3606344

0

0

0

2,037

 

Not significant

 

28

RAD52

3614681

0

0

0

322

 

Not significant

 

29

TGFB1

3356605

0

0

0

2,188

 

Not significant

 

30

TOP1

502960

0

0

0

3,484

 

Not significant

 
  1. For each gene, symbol and Clone ID are indicated. M, T and T&M columns (1 = present, 0 = absent) specify, in the respective group of samples, which genes were statistically differentially expressed using microarrays (α = 0.01); italics refers to genes for which differential expression was 'not significant'. The relative expression levels recorded with microarrays are indicated as the ratio between resistant and sensitive samples, specified as negative (down-regulated) or positive (up-regulated) values, together with the intensity measured in resistant colon tumors. Adjusted p values were computed using z statistics with false discovery rate corrections, α = 0.01; columns 'Min p value' and 'Max p value' refer to lower and upper bound p values, respectively.