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Table 1 Selection of 30 genes considered for further Q-PCR analysis

From: Deciphering cellular states of innate tumor drug responses

  Symbol Clone ID M T T&M All tumor samples (T&M)
       Intensity Ratio Min-value Max P value
1 ABCA2 3508171 0 0 1 411 -1.4 4.36E-05 4.93E-05
2 ABL1 345666 1 0 0 569 -1.5 1.44E-04 1.44E-04
3 CASP1 486506 0 1 0 714 1.9 6.30E-06 6.93E-06
4 CHEK1 3530606 1 0 1 1,901 1.6 1.66E-05 3.89E-05
5 CHEK2 3532866 0 0 1 2,624 1.4 2.72E-05 3.77E-05
6 COL4A2 3507072 0 0 1 5,813 -1.6 7.86E-03 7.86E-03
7 COL6A1 3506644 1 1 1 4,268 -2.6 4.43E-12 3.63E-02
8 COL6A2 3347413 1 0 1 3,906 -4.3 1.37E-11 1.31E-02
9 FOS 3688670 1 0 1 8,312 -1.7 7.39E-05 1.28E-04
10 HRASLS3 3051149 0 1 0 1,814 -1.7 6.22E-05 6.22E-05
11 LAMB1 428443 1 0 1 2,747 -1.5 5.06E-06 2.93E-04
12 MAD2L1 2964388 1 0 1 4,141 1.6 2.94E-05 1.99E-04
12 MMP11 725180 1 0 1 2,917 -2.3 1.78E-05 3.42E-02
14 PEA15 3346270 0 0 1 1,366 -1.3 3.48E-04 3.48E-04
15 RAD51 3139011 1 0 0 1,630 1.9 9.78E-03 9.78E-03
16 RECQL4 3634266 1 0 1 3,372 1.6 9.13E-06 1.76E-05
17 RERG 3357341 1 1 1 294 -3.6 1.17E-05 3.63E-02
18 RRAGD 3536088 1 0 1 596 -2.6 6.70E-07 4.35E-02
19 SERPINF1 2961120 1 0 1 1,902 -1.5 8.33E-10 2.74E-05
20 TGFBI 2958878 1 1 1 13,900 -2.4 5.43E-10 1.31E-02
21 TOP2B 470615 1 0 1 495 1.5 6.15E-06 2.34E-04
22 TP53 3544714 1 0 1 4,178 1.8 1.06E-06 1.32E-05
23 BCL2 232714 0 0 0 787   Not significant  
24 CES2 4298532 0 0 0 6,538   Not significant  
25 E2F4 3504728 0 0 0 5,620   Not significant  
26 ITGB6 759142 0 0 0 648   Not significant  
27 JUN 3606344 0 0 0 2,037   Not significant  
28 RAD52 3614681 0 0 0 322   Not significant  
29 TGFB1 3356605 0 0 0 2,188   Not significant  
30 TOP1 502960 0 0 0 3,484   Not significant  
  1. For each gene, symbol and Clone ID are indicated. M, T and T&M columns (1 = present, 0 = absent) specify, in the respective group of samples, which genes were statistically differentially expressed using microarrays (α = 0.01); italics refers to genes for which differential expression was 'not significant'. The relative expression levels recorded with microarrays are indicated as the ratio between resistant and sensitive samples, specified as negative (down-regulated) or positive (up-regulated) values, together with the intensity measured in resistant colon tumors. Adjusted p values were computed using z statistics with false discovery rate corrections, α = 0.01; columns 'Min p value' and 'Max p value' refer to lower and upper bound p values, respectively.