Directed acyclic graph representation of ontology terms. Association tree of the GO terms found significantly associated with in vivo innate drug responses. Bracketed numbers refer to the framework of the GO hierarchy and arrows indicate direct parent-child links. Relevant terms enriched in differentially expressed genes were computed using the GoMiner system . Terms related to categories enriched in down-regulated genes, up-regulated genes or both down- and up-regulated genes are colored in green, red and orange, respectively, and the corresponding adjusted p values are indicated. Squares and triangles refer, respectively, to the terms relevant in the NODE547X and NODE519X gene modules.