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Table 2 Receptors and signaling proteins associated with semaphorins

From: The semaphorins

Semaphorin

Binding receptors (with representative references)

Signaling proteins (with representative references)

'Reverse' signaling (with representative references)

Sema-1a

PlexA [158,159]

OTK [168], Gyc76c [169], MICAL [170], Nervy [171], PKA [171], Rac [172]

ena [50]

Sema-1b

PlexA [158]

-

-

Sema-2a

-

-

-

Sema-2b

-

-

-

Sema3A

Npn-1 [160,161], proteoglycans [162]

PlexA1, A2, A3, A4 [165,173,174], PlexD1 [175], VEGF receptor [176], L1CAM [177], integrins [61], α2-chimaerin [178], Cdc42 [179], Cdk5 [180], cGKI/PKG [181,182], Calcium channels [12], cofilin [183], CRAM [184], CRMP [185], FARP2 [45], Fes [184], Fyn [180], Go/Gi [185], guanylate cyclase [186], GSK-3 [187], LIM kinase [183], 12/15-lipoxygenase [188], MAP kinases [176], MLCK [189], nNOS [190], PI 3-kinase [181], PIPKIγ661 [45], PKA [181], PTEN [191], Rac [192], Rap1 [193], Rho [194], Rnd [195], ROCK [181], R-Ras [45]

-

Sema3B

Npn-1 [125], Npn-2 [125]

NrCAM [126], FAK [126], MAP kinases [126], Src [126]

-

Sema3C

Npn-1 [163], Npn-2 [163]

PlexD1 [196], MLCK [189], ROCK [189]

-

Sema3D

Npn-1 [164]

-

-

Sema3E

Npn-1 [164], PlexD1 [130]

Ca2+ channels [129], MAP kinases [129], PKC [129], Ras [129]

-

Sema3F

Npn-2 [163], Npn-1 [163]

PlexA3, A4 [173,174], NrCAM [127], E-cadherin [197], Beta-catenin [197], PI 3-kinase [198], MAP kinases [198]

-

Sema3G

Npn-2 [83]

-

-

Sema4A

Tim-2 [84]

ROCK [139]

-

Sema4B

-

-

PSD-95 [87]

Sema4C

-

-

PSD-95 [90], GIPC [207], norbin [208]

Sema4D

PlexB1 [165], PlexB2 [166], CD72 [167]

Met [147], Ron [199], ErbB2 [200], PlexC1 [34], integrin [201], AKT [141], Gab1 [147], LARG [146], 12/15-lipoxygenase [201], p190RhoGAP [202], PDZ-RhoGEF [146], PI 3-kinase [141], Pyk2 [141], Ras [46,203], Rho [204], Rnd [205], Src [141], MAP kinases [203], Raf [203]

CD45 [142], serine kinase [209]

Sema4E

-

-

-

Sema4F

-

-

PSD-95 [95]

Sema5A

PlexB3 [149], HSPG [16], CSPG [16], Syn-3 [16]

Met [149]

-

Sema5B

-

-

-

Sema5C

-

-

-

Sema6A

PlexA4 [151]

-

EVL [15]

Sema6B

PlexA4 [151]

-

Src [39]

Sema6C

-

-

-

Sema6D

PlexA1 [152]

OTK [152], VEGF receptor 2 [152]

Abl [46]

Sema7A

PlexC1 [165]

Integrins [154], Arg [206], FAK [154], MAP kinases [154]

Kinase activity [4]

SemaVA

PlexC1 [156]

Integrins [31], cofilin [31], FAK [31]

-

SemaVB

PlexC1 [156]

-

-

  1. A hyphen indicates not known. Abbreviations: Abl, Abelson tyrosine kinase; AKT, AKT serine/threonine kinase; Arg, Abl-related tyrosine kinase; CAM, cell adhesion molecule; CD45, CD45 phosphatase; Cdk5, cyclin-dependent kinase 5; CRAM, CRMP-associated molecule; CRMP, collapsing response mediator protein; cGKI, cGMP dependent protein kinase I; CSPG, chondroitin sulfate proteoglycan; ErbB2, receptor tyrosine kinase; ena, enabled; EVL, ena/VASP-like protein; FAK, focal adhesion tyrosine kinase; FARP2, FERM domain-containing GEF; Fes, feline sarcoma tyrosine kinase; Fyn, Fyn tyrosine kinase; Gab1, GRB2 associated binding protein 1; GIPC, GAIP interacting protein carboxy terminus; GSK-3, glycogen synthase kinase-3; Gyc76c, receptor guanylate cyclase 76c; HSPG, heparin sulfate proteoglycan; LARG, leukemia-associated RhoGEF; Met, receptor tyrosine kinase; MICAL, molecule interacting with CasL; MLCK, myosin light chain kinase; nNOS, neuronal nitric oxide synthase; Npn, neuropilin; OTK, off-track receptor tyrosine kinase; PI 3-kinase, phosphatidylinositol 3-kinase; PIPKIγ661, PIP kinase type I; PKA, protein kinase A; PKC, protein kinase C; PKG, protein kinase G; Plex, plexin; Pyk2, Pyk2 tyrosine kinase; PSD-95, post-synaptic density protein; PTEN, PTEN phosphatase; ROCK, Rho-associated kinase; Ron, receptor tyrosine kinase; Src, Src tyrosine kinase; Syn-3, syndecan-3; Tim, T-cell immunoglobulin domain and mucin domain; VEGF, vascular endothelial growth factor.
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