Figure 1
Neurogenic zones in the adult mouse brain. Adult neurogenesis is best characterized in two zones in the adult mouse brain: the subventricular zone (SVZ) adjacent to the lateral ventricle (LV), where neurons are produced that subsequently migrate to the olfactory bulb via the rostral migratory stream (RMS); and the dentate gyrus (DG) of the hippocampus. The hippocampus (shown enlarged in the inset) consists of two interleaved layers of cells - the pyramidal cell layer (CA) and the dentate gyrus. Proliferating neural precursors and quiescent neural stem cells are found in a zone immediately adjacent to the dentate gyrus called the subgranular zone (SGZ).