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Table 1 Performance of our method with Escherichia coli orphan activities without independent sequence homology information

From: Predicting genes for orphan metabolic activities using phylogenetic profiles

EC number Description Responsible gene Rank
1.14.11.17 Taurine dioxygenase b0368/tauD 1,143
1.1.1.251 Fructose 6-phosphate aldolase b0825/fsa 1
1.1.1.264 L-idonate 5-dehydrogenase b4267/idnD 44.5
1.2.1.22 Lactaldehyde dehydrogenase b0356/adhC 1
1.2.1.22 Lactaldehyde dehydrogenase b1241/adhE 18
1.2.1.22 Lactaldehyde dehydrogenase b3588/aldB 208
1.2.1.22 Lactaldehyde dehydrogenase b1415/aldA 654
1.2.2.2 Pyruvate oxidase b0871/poxB 1,451
1.2.1.39 Phenylacetaldehyde dehydrogenase b1385/feaB 1
1.1.1.57 Mannonate oxidoreductase b4323/uxuB 71.5
1.1.1.77 Lacaldehyde reductase b2799/fucO 10
2.7.1.130 Tetraacyldisaccharide 4'kinase b0915/lpxK 1,507
2.6.1.66 Valine-pyruvate aminotransferase b3572/avtA 70.5
2.7.1.58 2-Dehydro-3-deoxygalactonokinase b3693/dgoK 68
2.7.1.73 Insosine kinase b0477/gsk 1,041
3.2.2.4 AMP nucleosidase b1982/amn 69
2.7.7.58 2,3-Dihydroxybenzoate adenylate synthase b0594/entE 30
4.1.2.20 5-Dehydro-4-deoxyglucarate aldolase b3126/garL 2,057.5
4.1.1.41 Methylmalonyl-CoA decarboxylase b2919/ygfG 889
4.1.1.47 Glyoxalate carboligase b0507/gcl 1
4.2.1.42 Galactarate dehydratase b3128/garD 757
4.2.1.6 galactonate dehydratase b3692/dgoA 1,841.5
4.2.1.7 Altronate hydrolase b3091/uxaA 25
5.3.1.22 Hydroxypyruvate isomerase b0508/hyi 33
6.2.1.30 Phenylacetate-CoA ligase b1398/paaK 9
  1. The subset of orphan activities, identified using the SWISS-PROT database [37], includes EC numbers with representative sequences exclusively from E. coli. We also included EC numbers with representative sequences in the TrEMBL database, but only if these were computationally annotated from E. coli sequences.