Figure 7
From: Predicting genes for orphan metabolic activities using phylogenetic profiles
Construction of a network from a list of metabolic reactions. The direct connections are established between the dependency pairs: gene pairs sharing metabolites (M) as reactants or products. An orphan activity (metabolic network gap) is marked by a question mark and surrounded by known metabolic genes. The first and second network layers around the gap are colored yellow and blue, respectively. E, enzyme.