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Table 2 P. falciparum gene families encoding exported proteins

From: Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites

Family Paralogs Transmembrane domains Exons Microarray data Comments
     R T S M Sp G  
PfEMP1 59 1 2 x x x x x x  
DnaJ I 3 0 1/4/5 1 0 0 1 0 0 DnaJ domains 1-3
DnaJ III 16 0/1 2 3 1 1 3 0 0 DnaJ domain 1
EMP3 2 0 2 2 2 1 2 1 0 MC proteins
GBP130 3 0 2 2 2 2 1 1 0 RBC surface proteins
FIKK kinases 20 0 3 4 4 0 4 0 0 Protein kinase domain
PfMC-2TM 10 2 2 0 2 0 0 0 0 MC proteins
RIFIN 160 2 2 3 6 2 2 1 0 RBC surface proteins
STEVOR 30 2 2 0 0 0 0 0 0 MC proteins
a/b_HYDa 4 1 × 2, 2 × 1 1 × 1, 1 × 7, 2 × 2 0 0 0 0 0 0 a/b hydrolases
a/b_HYDb 4 0 2 × 1, 2 × 2 0 1 1 0 0 0 a/b hydrolases
HYP1 2 0 2 1 1 0 1 0 0  
HYP2 3 1 × 2, 2 × 0 1 × 1, 2 × 2 0 0 0 0 0 0 Probably not a real family
PHISTa 23 0 2/3 2 1 2 2 1 1 Four alpha helices
PHISTb 23 0 2 13 10 6 6 2 3 Four alpha helices
PHISTc 16 0 2 9 4 2 7 1 0 Four alpha helices conserved
HYP4 8 1 2 0 0 0 0 0 0 Similar to HYP6
HYP5 7 1 2 0 0 0 0 0 0  
HYP6 3 2 2 0 0 0 0 0 0  
HYP7 3 2 2 0 0 0 0 0 0 Similar to HYP8
HYP8 2 2 2 2 1 0 2 0 0 Proteomics iRBC localisation
HYP9 5 1 2 1 2 0 0 0 0  
HYP10 2 1 2 0 0 0 0 0 0 May be GPI anchored
HYP11 5 0 2 × 1, 3 × 2 0 1 0 0 0 0 Similar to PHIST
HYP12 3 0 2 2 1 1 1 0 0  
HYP13 2 2 2 1 0 0 1 0 0 Similar to HYP5
HYP15 4 2 2 × 1, 2 × 2 0 0 0 1 0 0 Similar to HYP5
HYP16 2 1 × 1, 1 × 2 2 1 0 0 1 0 0 Conserved
HYP17 2 1 2 1 0 0 0 0 0  
  1. Approximately 75% of all 396 P. falciparum proteins predicted to be exported are organised in families. Counts in columns 5 to 10 represent the number of family members deemed to be expressed by this method for each life cycle stage (except PfEMP1). Abbreviations for life cycle stages in the microarray section are: R, ring; T, trophozoite; S, schizont; M, merozoite; Sp, sporozoite; G, gametocyte. GPI, glycosylphosphatidyl inositol; iRBC, infected red blood cell; MC, Maurer's clefts; RBC, red blood cell.