Table 2 Cytokine gene regulation
Cytokine | Signaling pathways/transcription factors |
|---|---|
G-CSF | NF-κB, C/EBPβ, Oct, post-transcriptional regulation |
IL-1α | NF-κB, AP-1, Sp1 |
IL-6 | NF-κB, AP-1, Sp1, IRF-1, C/EBPβ |
IL-10 | C/EBPβ, C/EBPδ, Sp1, cAMP/PKA |
MIP-1α | NF-κB, Ets, C/EBPβ, cAMP/PKA, posttranscriptional regulation |
RANTES | NF-κB, AP-1, IRF-1, IRF-3 |
TNFα | Egr-1, Ets/Elk, NF-κB, c-jun/ATF-2, cAMP/PKA, post-transcriptional regulation (p38 dependent) |