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Table 1 Predictors identified in the PCR minimal model

From: Identification of signaling components required for the prediction of cytokine release in RAW 264.7 macrophages

Cytokine

Signaling pathways

Ligands

G-CSF

JNK lg

PAF (-)

 

NF-κB p65

 
 

p38

 

IL-1α

JNK lg

IFNγ

 

NF-κB p65

IL-4

IL-6

cAMP (-)

IFNβ

 

JNK lg

IL-4

 

NF-κB p65

LPS

IL-10

JNK sh

IL-4

 

NF-κB p65

IL-6

MIP-1α

cAMP (-)

PAF (-)

 

JNK lg

 
 

p38

 
 

STAT1α

 

RANTES

JNK lg

LPS

 

NF-κB p65

 
 

STAT1β

 

TNFα

cAMP(-)

IFNγ

 

JNK lg

M-CSF

 

NF-κB p65

PAF (-)

 

p38

 
  1. (-), negative predictor.