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Table 2 DDI-PPI mapping: interactions involving only single-domain proteins

From: Evolutionary conservation of domain-domain interactions

Organisma E. coli yeast worm fly human
Number of PPIs (with known domains) (N) 497 2,418 335 2,068 1,633
Number of PPIs to which DDIs could be mapped (n) (%; n/N*100)
Median value of random networks (P value)
117 (24%)
92 (0.005)
284 (12%)
79 (<0.001)
60 (18%)
38 (<0.001)
217 (10%)
55 (<0.001)
400 (25%)
135 (<0.001)
  1. a Organism labeling: yeast: S. cerevisiae, worm: C. elegans, fly: D. melanogaster. For the analysis of each organism, DDIs in the structural database that are based on single-domain proteins of the respective organism were excluded. DDI, domain-domain interaction; PPI, protein-protein interaction.