Figure 1

A schematic description of the analysis. (a) A list of experimentally determined PPIs is compiled for each of the five organisms (E. coli, S. cerevisiae, C. elegans, D. melanogaster, and H. sapiens) from INTACT [32], DIP [19], and BIOGRID [33]. (b) A list of structurally derived DDIs is compiled from 3DID [12] and iPfam [13] databases. (c) The appropriate domains are assigned to each of the interacting proteins according to the definitions of the InterPro database [34]. (d) Based on the data complied in panels b and c, DDIs are mapped onto PPIs. (e) A list of PPIs with DDI assignments is compiled. (f) A list of the DDIs mapped onto PPIs is compiled. DDI, domain-domain interaction; PPI, protein-protein interaction.