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Table 2 Summary of DAVID Gene Ontology classification of target mRNA populations

From: Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors

Cellular function Gene Ontology group U2AF (%) PTB (%)
Gene expression Transcription, DNA-dependent 13.1 10.6
  Transcription from Pol II promoter 3.8 3.1
  Negative regulation of transcription from Pol II promoter 0.7 -
  DNA packaging 1.4 -
  Nuclear mRNA splicing, via spliceosome 1.2 -
  Translation 1.1 -
Cell cycle Cell proliferation 6.5 5.6
  Cell cycle 4.9 4.1
  Regulation of cell cycle 3 2.3
  G1/S transition of mitotic cell cycle 0.6 -
  Mitotic cell cycle 1.3 -
Apoptosis Death - 3
  Apoptosis - 2.8
  Negative regulation of apoptosis 0.9  
Ubiquitination Ubiquitin cycle 4.9 4.5
  Protein ubiquitination 2.6 2.1
Signaling Intracellular signaling cascade 6 6.8
  Small GTPase mediated signal transduction 1.9 2.6
Intracellular transport and vesicles Establishment of localization - 10.4
  Endosome organization and biogenesis - 0.4
  Endosome transport - 0.3
  Vesicle-mediated transport - 2.1
  1. In the U2AF and PTB columns, '-' indicates that enrichment was not significant relative to the proportion of array genes belonging to the Gene Ontology group (P > 0.001). PTB, polypyrimidine tract binding protein; U2AF, U2 small nuclear RNP auxiliary factor.