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Table 4 Highly regulated or reporter metabolites for the three possible pair-wise comparisons between the different carbon sources

From: Metabolic network driven analysis of genome-wide transcription data from Aspergillus nidulans

Ethanol versus glucose Ethanol versus glycerol Glycerol versus glucose
Reporter metabolite n P Reporter metabolite n P Reporter metabolite n P
Acetyl coenzyme A (mitochondrial) 12 2.1E-06 Oxaloacetate 13 7.6E-05 N-Carbamoyl-L-aspartate 3 1.0E-03
Coenzyme A (mitochondrial) 14 2.6E-06 Coenzyme A (mitochondrial) 14 1.2E-04 Carbamoyl phosphate 5 1.7E-03
Glyoxylate (glyoxysomal) 3 1.8E-05 Glyoxylate (glyoxysomal) 3 2.1E-04 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine 2 2.8E-03
Oxaloacetate 13 9.4E-05 Acetyl coenzyme A (mitochondrial) 12 2.7E-04 Glycogen 2 2.8E-03
Acetyl coenzyme A (glyoxysomal) 2 1.1E-04 Acetyl coenzyme A (glyoxysomal) 2 4.2E-04 Maltose 6 2.9E-03
Coenzyme A (glyoxysomal) 2 1.1E-04 Coenzyme A (glyoxysomal) 2 4.2E-04 Maltose (extracellular) 6 2.9E-03
Oxaloacetate (mitochondrial) 11 4.4E-04 Oxaloacetate (mitochondrial) 11 4.3E-04 L-glutamine 16 3.1E-03
Carnitine 2 4.9E-04 2-Oxoglutarate (mitochondrial) 9 4.9E-04 α-D-glucose 1-phosphate 4 3.4E-03
O-acetylcarnitine 2 4.9E-04 Citrate 1 5.6E-04 ATP 94 3.7E-03
Propanoyl-coenzyme A 3 6.1E-04 Phosphoenolpyruvate 6 8.5E-04 (R)-3-Hydroxy-3-methyl-2-oxobutanoate (mitochondrial) 2 4.4E-03
Maltose 6 7.0E-04 Fumarate (mitochondrial) 3 8.6E-04 (R)-2,3-dihydroxy-3-methylbutanoate (mitochondrial) 2 4.4E-03
Maltose (extracellular) 6 7.0E-04 α-D-glucose 1-phosphate 4 9.5E-04 Carbon dioxide 42 4.7E-03
O-acetylcarnitine (mitochondrial) 2 9.0E-04 Citrate (mitochondrial) 5 1.3E-03 S-acetyldihydrolipoamide (mitochondrial) 2 5.1E-03
Carnitine (mitochondrial) 2 9.0E-04 Carnitine 2 1.9E-03 Carbon dioxide (mitochondrial) 16 6.0E-03
O-acetylcarnitine (glyoxysomal) 2 9.0E-04 O-acetylcarnitine 2 1.9E-03 ADP 64 1.2E-02
  1. Shown are highly regulated or reporter metabolites for the three possible pair-wise comparisons between the different carbon sources, according to Patil and Nielsen [23]. 'n' denotes the number of neighbors of the reporter metabolite (the number of reactions in which it participates).