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Table 4 Highly regulated or reporter metabolites for the three possible pair-wise comparisons between the different carbon sources

From: Metabolic network driven analysis of genome-wide transcription data from Aspergillus nidulans

Ethanol versus glucose

Ethanol versus glycerol

Glycerol versus glucose

Reporter metabolite

n

P

Reporter metabolite

n

P

Reporter metabolite

n

P

Acetyl coenzyme A (mitochondrial)

12

2.1E-06

Oxaloacetate

13

7.6E-05

N-Carbamoyl-L-aspartate

3

1.0E-03

Coenzyme A (mitochondrial)

14

2.6E-06

Coenzyme A (mitochondrial)

14

1.2E-04

Carbamoyl phosphate

5

1.7E-03

Glyoxylate (glyoxysomal)

3

1.8E-05

Glyoxylate (glyoxysomal)

3

2.1E-04

2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine

2

2.8E-03

Oxaloacetate

13

9.4E-05

Acetyl coenzyme A (mitochondrial)

12

2.7E-04

Glycogen

2

2.8E-03

Acetyl coenzyme A (glyoxysomal)

2

1.1E-04

Acetyl coenzyme A (glyoxysomal)

2

4.2E-04

Maltose

6

2.9E-03

Coenzyme A (glyoxysomal)

2

1.1E-04

Coenzyme A (glyoxysomal)

2

4.2E-04

Maltose (extracellular)

6

2.9E-03

Oxaloacetate (mitochondrial)

11

4.4E-04

Oxaloacetate (mitochondrial)

11

4.3E-04

L-glutamine

16

3.1E-03

Carnitine

2

4.9E-04

2-Oxoglutarate (mitochondrial)

9

4.9E-04

α-D-glucose 1-phosphate

4

3.4E-03

O-acetylcarnitine

2

4.9E-04

Citrate

1

5.6E-04

ATP

94

3.7E-03

Propanoyl-coenzyme A

3

6.1E-04

Phosphoenolpyruvate

6

8.5E-04

(R)-3-Hydroxy-3-methyl-2-oxobutanoate (mitochondrial)

2

4.4E-03

Maltose

6

7.0E-04

Fumarate (mitochondrial)

3

8.6E-04

(R)-2,3-dihydroxy-3-methylbutanoate (mitochondrial)

2

4.4E-03

Maltose (extracellular)

6

7.0E-04

α-D-glucose 1-phosphate

4

9.5E-04

Carbon dioxide

42

4.7E-03

O-acetylcarnitine (mitochondrial)

2

9.0E-04

Citrate (mitochondrial)

5

1.3E-03

S-acetyldihydrolipoamide (mitochondrial)

2

5.1E-03

Carnitine (mitochondrial)

2

9.0E-04

Carnitine

2

1.9E-03

Carbon dioxide (mitochondrial)

16

6.0E-03

O-acetylcarnitine (glyoxysomal)

2

9.0E-04

O-acetylcarnitine

2

1.9E-03

ADP

64

1.2E-02

  1. Shown are highly regulated or reporter metabolites for the three possible pair-wise comparisons between the different carbon sources, according to Patil and Nielsen [23]. 'n' denotes the number of neighbors of the reporter metabolite (the number of reactions in which it participates).