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Table 1 Over-represented GO groups and promoter consensus sequences

From: Growth-rate regulated genes have profound impact on interpretation of transcriptome profiling in Saccharomyces cerevisiae

Cluster

GO group

Cluster 1

Metabolism

 

Biosynthesis

 

Cell organization and biogenesis

 

Amino acid metabolism

 

Nucleotide metabolism

 

Protein metabolism

 

Nucleotide biosynthesis

 

Carboxylic acid metabolism

 

tRNA modification

 

Ribosome biogenesis and assembly

 

Nucleobase, nucleoside, nucleotide, and nucleic acid metabolism

 

Glutamate biosynthesis

 

TGAAAA/TTTTCA

 

GAAAAA/TTTTTC

Cluster 2

Cell growth and/or maintenance

 

Mitotic cell cycle

 

Physiologic process

 

Nuclear organization and biogenesis

 

Organelle organization and biogenesis

 

Cytoplasm organization and biogenesis

 

Cytoskeleton organization and biogenesis

 

Morphogenesis

 

Reproduction

 

AAATTT/AAATTT

 

GAAAAA/TTTTTC

Cluster 3

Ribosome biogenesis

 

Cytoplasm organization and biogenesis

 

RNA metabolism

 

Aerobic respiration

 

Nucleobase, nucleoside, nucleotide, and nucleic acid metabolism

 

Cell growth and/or maintenance

 

AATTCA/TGAATT

Cluster 4

Lipid metabolism

 

Steroid metabolism

 

Amino acid biosynthesis

 

Glutamine family amino acid biosynthesis

 

Cell growth and/or maintenance

 

Arginine biosynthesis

 

ATAACA/TGTTAT

Cluster 5

Cell growth and/or maintenance

 

Protein modification

 

Protein amino acid phosphorylation

 

Organelle organisation and biogenesis

 

Cell wall organization and biogenesis

 

Cell organization and biogenesis

 

Signal transduction

 

Cytokinesis

 

Amino acid biosynthesis

Cluster 6

DNA replication and chromosome cycle

Cluster 7

-

Cluster 8

Transport

 

GAAAAA/TTTTTC

Cluster 9

Steroid metabolism

 

Alcohol metabolism

 

Ergosterol biosynthesis

 

Ammonium transport

 

Biological process unknown

Cluster 10

Carboxylic acid metabolism

 

Sporulation

 

Nitrogen utilization

 

Carnitine metabolism

 

Main pathways of carbohydrate metabolism

 

Energy pathways

 

Sporulation

Cluster 11

RNA splicing

 

mRNA metabolism

 

Regulation of transcription

Cluster 12

Meiosis

 

Meiotic prophase I

 

Nuclear division

 

Response to stimulus

 

AAGGGG/CCCCTT

Cluster 13

Autophagy

 

Vitamin metabolism

 

Fatty acid β-oxidation

 

Response to water

 

Biological process unknown

 

AAGGGG/CCCCTT

 

AGGGAG/CTCCCT

 

AAAAGG/CCTTTT

 

AAAGGG/CCCTTT

 

AGGGGG/CCCCCT

  1. Shown are over-represented GO [61,62] groups and promoter consensus sequences in the 13 clusters of growth regulated genes. GO groups describing a cellular process with P < 10-4 were considered significant and included in the table. If the same set of genes was found in two or more neighbouring GO groups, only one GO term is included [63]. Hexamers, found in the 800 base pair upstream region of ORFs in a cluster, were considered significantly over-represented when E < 10-2 [64,65]. GO, Gene Ontology; ORF, open reading frame.