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Figure 3 | Genome Biology

Figure 3

From: Growth-rate regulated genes have profound impact on interpretation of transcriptome profiling in Saccharomyces cerevisiae

Figure 3

Comparison between conditions with changes in growth rate. From left to right separated by blue, vertical lines: the fold change in transcript levels between cells grown at lowest (average of μ = 0.02 and 0.05 per hour) and the highest growth rate (average of 0.33 per hour); cells in lag phase (four time points: 0, 0.01, 0.05, and 0.1 hours [5]); cells in postdiauxic phase (eight time points: 36, 51, 62, 83, 107, 130, 178, and 212.25 hours [5]); stress response, galactose (four time points: 20, 40, 60, and 140 min [6]); and ESR transcript profiles (right of blue vertical line) and 13 stress condition obtained from the work by Brown and coworkers (Figure 3 in their report [7]). The approximately 900 ESR genes were originally identified by hierarchical clustering of all yeast transcripts from 142 microarray experiments [7]. The transcripts formed two distinct clusters of transcript that responded similarly to 13 stress condition, and the corresponding genes were denoted the ESR genes [7]. Transcript levels from all conditions are based on a global normalization of the DNA arrays, in which it is assumed that the cellular mRNA levels remain constant in response to stress or changes in the specific growth rate (also see Additional data file 5). ESR, environmental stress response.

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