Figure 5

Analysis of coexpressed sets of genes across human tissues and cell lines. The figure shows five clusters of genes with distinct expression profiles from Genomics Institute of the Novartis Research Foundation SymAtlas [17]: (a) transcripts with widespread and low-level expression in most tissues/cell types; (b) transcripts expressed in brain and immune tissues and cell types but under-expressed in other tissues; (c) transcripts with enriched expression in brain tissues and low levels of expression in other tissues; (d) transcripts or splice forms enriched in hematopoietic derived immune cell types; and (e) transcripts or splice forms under-expressed in immune tissues and cell types. The tables to the right of each expression cluster shows the five most enriched TFBSs found in that cluster, and lists the TFBS name, the observed count number of hits of that TFBS in intergenic and intronic MCEs, the fold increase over that expected by chance, and the significance of enrichment in the cluster. Available PWM logos for all significantly enriched TFBSs (P < 0.05) are also displayed. MCE, most conserved element; PWM, positional weight matrix; TFBS, transcription factor binding site.