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Table 1 Yeast protein-interaction assay false-positive rates: yeast datasets

From: How complete are current yeast and human protein-interaction networks?

Dataset Number of interactions Derived false-positive rate* (%) Published false-positive rate (%) Average false-positive rate (%)
Uetz et al. [35] 854 46 [32] 32 [24],47 [44], 50 [37], 51 [42] 45
Ito [36] 4,393 89 [32] 71 [24], 78 [41], 85 [37], 91 [44] 83
Gavin et al. [16] 3,180 68 [32] 14 [24], 22 [4], <72 (upper bound [20]) 35
Ho et al. [17] 3,618 83 [32], 81, 82, 80 55 [24], <97 (upper bound [20]) 76
Jansen et al. [22] 15,922 81, 79 - 80
Gavin et al. [27] 18,137 78, 82, 86 - 82
Krogan et al. [28] 14,317 (7,123 core) 75, 79, 66 (59, 65, 37 core) - 73 (54 core)
Overall 51,419    72
  1. *This interaction assay false-positive rate is taken from D'haeseleer and Church [32] or derived using the method therein. Multiple values derive from choosing either the GRID [2] or MIPS [33] reference sets. This interaction assay false-positive rate is calculated with the EPR server of Deane et al. [42]. The mean of four values estimated from Table S3 of Lee et al. [24] by fitting the interaction set as a linear combination of true-positive (small scale interactions) and false-positive (random pairs) interactions.