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Table 2 Summary of effective prediction rules obtained by Bayesian classification

From: An inventory of yeast proteins associated with nucleolar and ribosomal components

Hs

At

Ue

It

Kr

Ga

Ho

Prediction: associated with nucleolar or ribosomal component?

0

0

0

0

0

0

0

No

0

0

0

0

0

0

1

No

0

0

0

0

0

1

0

No

0

0

0

0

0

1

1

No

0

0

0

0

1

0

0

No

0

0

0

0

1

0

1

No

0

0

0

0

1

1

0

No

0

0

0

1

0

0

0

No

0

0

0

1

0

1

0

No

0

0

0

1

1

0

0

No

0

0

0

1

1

1

0

No

0

0

1

0

0

0

0

No

0

0

1

0

0

0

1

No

0

0

1

0

0

1

0

No

0

0

1

0

1

0

0

No

0

0

1

0

1

1

0

No

0

0

1

1

0

0

0

No

0

0

1

1

0

1

0

No

0

1

0

0

0

0

0

No

0

1

0

0

0

1

0

No

0

1

0

0

1

0

0

No

1

0

0

0

0

0

0

No

1

0

0

0

0

1

0

No

1

0

0

0

1

0

0

No

1

0

0

1

0

0

0

No

1

0

1

0

0

0

0

No

0

0

0

0

1

1

1

Yes

0

0

1

0

1

1

1

Yes

0

0

1

1

1

1

0

Yes

0

1

0

0

0

0

1

Yes

0

1

0

1

0

1

0

Yes

0

1

1

0

1

1

1

Yes

1

0

0

0

0

0

1

Yes

1

0

0

0

1

0

1

Yes

1

0

0

0

1

1

0

Yes

1

0

0

0

1

1

1

Yes

1

0

0

1

1

1

0

Yes

1

0

1

0

0

1

0

Yes

1

0

1

0

1

0

0

Yes

1

0

1

0

1

1

0

Yes

1

0

1

1

1

0

0

Yes

1

1

0

0

0

0

0

Yes

1

1

0

0

0

0

1

Yes

1

1

0

0

0

1

0

Yes

1

1

0

0

1

0

0

Yes

1

1

0

0

1

1

0

Yes

1

1

0

1

1

0

0

Yes

1

1

1

0

0

1

0

Yes

1

1

1

0

1

1

0

Yes

  1. Our Bayesian classification approach assigns a distinct prediction to each possible binary pattern that could be associated with a protein. With the seven data sources used here, only a limited number of 128 different combinations of binary evidences is possible. Here, all binary patterns that occur in our data set are enumerated. They are supplemented by the prediction result to illustrate which input data generates which prediction. Note that neither a single protein interaction nor a single occurrence in nucleoli of model organisms is sufficient for a positive prediction, and that evidence from three protein interaction experiments is necessary for a positive prediction in the absence of evidence based on orthologs in nucleolar preparations of model organisms. Column headers denote the data source: Hs, orthology to human nucleolar protein; At, orthology to mouse-ear cress nucleolar protein; Ue, link to nucleolar protein via Y2H interaction in Uetz dataset; It, link to nucleolar protein via Y2H interaction in Ito dataset; Kr, link to nucleolar protein via participation in a complex in Krogan data set; Ga, link to nucleolar protein via participation in a complex in Gavin data set; Ho, link to nucleolar protein via participation in a complex in Ho data set.