Figure 6

Hierarchical clustering of gene expression patterns of ribosomal and processosomal protein genes. The central plot shows color-coded expression ratios as supplied in the ROSETTA expression compendium [47] for genes encoding ribosomal and 90S-processosomal proteins. Genes vary along the horizontal axis, expression experiments vary along the vertical axis. Top: 90S-processosomal genes are marked in black, ribosomal protein genes are marked in white. Bottom: hierarchical clustering yields two large clusters, here marked in cyan and in yellow, that comprise approximately 80% of all ribosomal/processosomal genes (171 of 211). Only genes of these clusters are shown here. Note that only three genes are not clustered according to their membership to either the ribosome or the 90S processosome. The separation of the 90S processosomal and ribosomal protein genes by hierarchical clustering (an unsupervised approach) confirms that the ribosomal and 90S processosomal expression programs are distinct from each other (Figure 5).