Figure 4

Phylogenetic profiling of the 90S processosome. Phylogenetic profiles of known yeast 90S processosome proteins across 84 organisms. Abbreviations given on the top of the plot represent organism names (first three letters for genus and first three letters of species names; see Materials and methods for a translation of abbreviations into organism names). Further taxonomic annotation is given on the bottom of the plot. Yeast open reading frame identifiers are given on the left side, and gene names and descriptions are given on the right side of the plot. The significance of sequence similarity is visualized by different shades of gray that reflect the logarithmic expectation (E) value from reciprocal BLAST searches (shown at the bottom of the figure). Here, the E values of BLAST searches using target proteome sequences as queries versus the yeast proteome reference database are shown. The genes are ordered according to hierarchical clustering (see Materials and methods). Note that there are only a few proteins with many prokaryotic orthologs when compared to Figure 3.