From: Transcriptional response to alcohol exposure in Drosophila melanogaster
Gene symbol | P-element insertion site | Biological process | Canton S* background | Mean elution time (min)†(1st exposure) | Time shift (between 1st and 2nd exposures) |
---|---|---|---|---|---|
Slow down-regulation | |||||
   Fkbp13 | In 1st intron | Protein folding | A | 6.7 ± 0.25 | 2 min‡ ↑ |
   Sir2 | 410 bp in exon 1 | Regulation of transcription, DNA-dependent; chromatin silencing | B | 5.0 ± 0.2 | 2 min§ ↓ |
   BubblegumH | In 1st intron | Fatty acid metabolism | C | 6.2 ± 0.21 | 0.5 min (NS) ↓ |
Acute up-regulation | |||||
   CG1516H | 125 bp upstream of transcription initiation site of the longest transcript | Pyruvate metabolism; fatty acid biosynthesis | E | 4.2 ± 0.12 | 1 min (NS) ↑ |
Transient up-regulation | |||||
   Thor | 431 bp upstream of transcription initiation site | Negative regulation of translational initiation; response to stress; defense response | E | 7.5 ± 0.11; R | 2.5 min§ ↑ |
   Pyruvate dehydrogenase kinaseH | 47 bp in exon 1 | Pyruvate metabolism; tricarboxylic acid cycle; regulation of phosphate metabolism | F | 7.4 ± 0.30; R | 1 min‡ ↑ |
Slow up-regulation | |||||
   v(2)k05816H | 281 bp upstream of transcription initiation site | Fatty acid biosynthesis | A | 6.1 ± 0.25 | 1 min (NS) ↑ |
   elbow BH | 888 bp upstream of transcription initiation site | Tracheal system development | A | 6.8 ± 0.26 | 0.5 min (NS) ↓ |
   Hormone receptor-like in 38 | 1,428 kb upstream of transcription initiation site | Regulation of transcription from RNA polymerase II promoter; intracellular signaling cascade | A | 5.8 ± 0.22; S | 1 min (NS) ↓ |
   nuclear falloutH | In 4th intron | Actin cytoskeleton reorganization; microtubule-based process | B | 6.6 ± 0.30 | 1 min (NS) ↓ |
   CG12505 | 136 bp upstream of transcription initiation site | Unknown | B | 4.8 ± 0.18 | 1.5 min‡ ↓ |
   tramtrack | 219 bp in exon 1 of the longest transcript | Regulation of transcription from RNA polymerase II promoter; peripheral nervous system development | B | 5.8 ± 0.20 | 1 min§ ↑ |
   CG9086H | 50 bp in exon 1 | Protein ubiquitination | B | 6.1 ± 0.18 | 1.5 min§ ↓ |
   CG6767 | In 1st intron | Nucleotide biosynthesis, metabolism | B | 7.0 ± 0.16; R | 0.5 min (NS) ↑ |
   CG32434 | 36 bp upstream of transcription initiation site | Unknown | B | 6.1 ± 0.26 | 2 min§ ↓ |
   frizzled 2H | 147 bp in exon 1 | Signal transduction; G-protein coupled receptor protein signaling pathway | E | 5.9 ± 0.13; R | 2 min§ ↑ |
   Malic enzymeH | In 1st intron | Malate metabolism; tricarboxylic acid cycle | E | 6.4 ± 0.15; R | 6 min¶ ↑ |
   CG9238 | 73 bp in exon 1 | Glycogen metabolism | F | 7.6 ± 0.12; R | 3.5 min§ ↑ |
   spalt majorH | 154 bp upstream of transcription initiation site | Tracheal system development; sensory organ development; negative regulation of transcription | F | 6.9 ± 0.18; R | 0.5 min (NS) ↓ |
   lola | In 1st intron | Transmission of nerve impulse; regulation of transcription from RNA polymerase II promoter | F | 6.1 ± 0.11; R | 3 min§ ↑ |