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Table 1 Probe sets with altered transcriptional regulation after ethanol exposure with q < 0.001

From: Transcriptional response to alcohol exposure in Drosophila melanogaster

Probe set ID

p value

Gene name

Biological process

Changes in expression

1623332_at

1.91E-05

CG31106

Transmission of nerve impulse; carbohydrate metabolism

Transient up-regulation

1623605_a_at

2.20E-05

Serpin-27A (M,H)*

Toll signaling pathway; defense response

Transient up-regulation

1624662_at

2.20E-05

CG11414

Protein ubiquitination

Acute up-regulation

1624736_a_at

2.20E-05

CG11878

Unknown

Slow up-regulation

1625193_at

2.20E-05

CG31272

Lipid metabolism; neurotransmitter secretion; transport

Slow up-regulation

1626882_at

2.35E-05

Pinocchio

Olfactory behavior;response to chemical stimulus

Transient up-regulation

1627080_at

5.07E-05

CG14893

Unknown

Slow up-regulation

1627385_at

6.86E-05

minidiscs

Amino acid transport, metabolism

Transient down-regulation

1628229_at

6.86E-05

Trypsin 29F

Proteolysis

Slow up-regulation

1628494_a_at

6.86E-05

CG33525

Negative regulation of transcription, DNA-dependent

Slow up-regulation

1628647_at

1.06E-04

CG33110

Fatty acid biosynthesis; very-long-chain fatty acid metabolism

Slow up-regulation

1628947_s_at

1.06E-04

Ecdysone-inducible gene L2 (M,H)*

Cell adhesion

Acute up-regulation

1629012_at

1.06E-04

period (M,H)*

Long-term memory; circadian rhythm; signal transduction; negative regulation of transcription from RNA polymerase II promoter

Transient down-regulation

1629592_at

1.32E-04

ηTrypsin (M,H)*

Proteolysis

Transient down-regulation

1629617_at

1.44E-04

cabut

Regulation of transcription from RNA polymerase II promoter; JNK cascade; autophagic cell death

Acute up-regulation

1630302_at

1.66E-04

Odorant-binding protein 99d

Transport; autophagic cell death

Slow up-regulation

1631406_at

1.66E-04

CG3106 (M,H)*

Unknown

Transient down-regulation

1632222_a_at

2.25E-04

CG17752

Extracellular transport; cation transport

Slow up-regulation

1632228_at

2.58E-04

CG10505

Response to toxin; extracellular transport; defense response

Slow up-regulation

1633700_at

2.78E-04

antennal protein 10 (M,H)*

Sensory perception of chemical stimulus

Acute down-regulation

1633794_a_at

3.22E-04

antennal protein 5

Signal transduction

Acute down-regulation

1633913_at

3.80E-04

Cytochrome P450-6a8

Electron transport; steroid metabolism; lauric acid metabolism

Slow up-regulation

1634318_at

3.98E-04

lush

Response to ethanol; sensory perception of smell; olfactory behavior

Acute down-regulation

1634591_at

4.38E-04

Rpd3

Regulation of transcription from RNA polymerase II promoter; determination of adult life span; gene silencing

Slow up-regulation

1635815_at

5.47E-04

CG5819 (M,H)*

Transmission of nerve impulse; cell adhesion

Acute up-regulation

1636202_s_at

6.40E-04

CG8931

Transport

Transient up-regulation

1636611_at

6.40E-04

Pheromone-binding protein-related protein 1 (M)*

Signal transduction; sensory perception; response to pheromone

Acute down-regulation

1636771_at

6.40E-04

CG8562

Proteolysis

Slow down-regulation

1638066_at

6.40E-04

CG9238

Glycogen metabolism

Slow up-regulation

1638246_at

6.52E-04

Olfactory-specific E

Signal transduction; response to pheromone; transport

Acute down-regulation

1638452_at

7.01E-04

CG6733

Proteolysis

Slow down-regulation

1639368_at

7.73E-04

CG5804

Lipid transport; cell acyl-CoA homeostasis

Transient down-regulation

1639934_at

7.77E-04

capulet

Actin filament organization; bristle morphogenesis

Slow up-regulation

1640755_at

8.83E-04

Picot

Phosphate metabolism; extracellular transport; cation transport

Slow up-regulation

  1. Transcripts that show sustained altered expression after the first exposure to ethanol are indicated as 'acutely up- or down-regulated genes'. Transcripts that show altered expression only after the second exposure are designated as 'slowly up- or down-regulated genes'. The designation 'transient up-regulation' refers to genes that show increased expression after the first exposure to ethanol, but a return to control levels 2 h later after the second exposure. *Genes that have human (H) and/or mouse (M) orthologues.