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Table 1 Distribution and Sec evolutionary trends of 25 bacterial selenoprotein families

From: Dynamic evolution of selenocysteine utilization in bacteria: a balance between selenoprotein loss and evolution of selenocysteine from redox active cysteine residues

Selenoprotein family Number of selenoproteins Sec/Cys conversion events Selenoprotein loss events
   Sec→Cys Cys→Sec  
Formate dehydrogenase alpha subunit (FdhA) 103 7 - 2
Selenophosphate synthetase (SelD) 38 3 - 6
Coenzyme F420-reducing hydrogenase delta subunit (FrhD)a 19 3 3 5
Heterodisulfide reductase, subunit A (HdrA)a 16 - 2 4
Peroxiredoxin (Prx)a 12 - 5 -
HesB-like 11 2 - 3
Glycine reductase selenoprotein A (GrdA) 11 - - 4
Glycine reductase selenoprotein B (GrdB)a 11 - - 6
SelW-likea 10 - - 3
Prx-like thiol:disulfide oxidoreductasea 8 - 3 -
Thioredoxin (Trx)a 7 - - -
Coenzyme F420-reducing hydrogenase α subunit (FrhA)a 6 - 2 -
Fe-S oxidoreductase (GlpC) 5 - 2 -
Proline reductase (PR)a 5 - - -
DsbA-likea 4 - 1 1
Glutaredoxin (Grx)a 3 - 3 -
Thiol:disulfide interchange proteina 3 - 1 -
AhpD-like (COG2128)a 2 - 2 -
ArsC-likea 2 - 1 2
DsbG-likea 2 - 2 -
Distant AhpD homologa 2 - 1 -
Homolog of AhpF, amino-terminal domaina 2 - 2 1
DsrE-likea 1 - 1 -
NADH oxidase 1 - 1 1
Glutathione peroxidase (GPx)a 1 - 1 -
Total 285 15 33 38
  1. aHomologs of thiol-based oxidoreductases.