Figure 3

CLICs of OR genes. (a) CLIC (columns) are shown by human genomic order (see Table 3), with human chromosome numbers indicated (top ticked line). For CLICs that do not contain human clusters, the order was determined by the human location that is syntenic to the region of the mouse OR cluster (Additional data file 1). For each species (h = human, m = mouse, r = rat, d = dog, o = opossum, c = chicken, n = consensus gene count) circle size is proportional to log2(n - 1), where n is the number of genes in the OR clusters within the CLIC. All multi-species CLICs are enumerated (#i at bottom); nonhuman single species CLICs are not shown. (b-d) Detailed depiction of three CLICs indicated by the corresponding capital letter above the CLIC column in panel a. To the left of panels b-d, clusters are represented by circles (colored for species, as in panel a), with gene count indicated. Lines connect every two clusters sharing syntenic orthologs. To the right of panels b-d are schematic genomic representations of the clusters, with OR gene groups in species color and OR family indicated. Grey bars represent flanking non-OR genes (HUGO nomenclature symbols indicated [57]); TRA@ is the T-cell receptor alpha locus. Multiple rows for the same species indicate the inclusion of clusters from multiple chromosomes in the CLIC. A break in local or large-scale synteny is marked by a broken line. For the complete list of the genomic coordinates of all analyzed genes, see Additional data file 2. CLIC, clusters in conservation; OR, olfactory receptor.