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Table 5 The prognostic added value of the MPI

From: A consensus prognostic gene expression classifier for ER positive breast cancer

Model JRH-1 UPP JRH-2
Grade 3.85 2.55 2.15
Grade + MPI* 5.85 (2.49-13.72) 2.85 (1.79-4.51) 10.60 (2.79-40.20)
Grade + MPI** 4.62 (2.15-9.91) 2.90 (1.83-4.58) 8.14 (2.11-31.31)
Node Status 2.64 4.03 2.36
Node Status + MPI* 2.98 (1.48-6.01) 4.71 (2.83-7.86) 14.07 (2.08-94.84)
Node Status + MPI** 3.09 (1.53-6.23) 4.40 (2.74-7.06) 11.79 (1.86-74.44)
Size 4.16 3.18 3.04
Size + MPI* 5.40 (2.51-11.62) 3.41 (2.16-5.38) 5.21 (2.29-11.84)
Size + MPI** 4.88 (2.35-10.13) 3.65 (2.29-5.81) 4.51 (2.08-9.77)
NPI 5.16 3.82 3.78
NPI + MPI* 5.85 (2.54-13.47) 4.02 (2.52-6.41) 19.11 (2.62-139.3)
NPI + MPI** 4.93 (2.30-10.56) 4.04 (2.53-6.44) 25.23 (2.53-251.6)
  1. For each standard prognostic index SPI (grade, node status, size and NPI) we compare their D-index with the D-index of the corresponding equal-weight hybrid prognostic model, defined by a hybrid prognostic index HPI, where HPI ~ SPI + MPI* or HPI ~ SPI + MPI** (see Materials and methods). 95% CI for the hybrid prognostic model D-index values are shown in brackets. MPI* denotes the index of the optimal 52-gene classifier. MPI** denotes the index of the 17-gene classifier. For JRH-2 only 36 samples with NPI information were available.