Table 3 Top prognostic genes in ER+ breast cancer
From: A consensus prognostic gene expression classifier for ER positive breast cancer
UniGene symbol | Coefficient sign | Cytoband | GO |
|---|---|---|---|
RACGAP1 | + | 12q13.12 | GTPase activator activity, electron transporter activity |
STK6 | + | 20q13.2-q13.3 | ATP binding, mitosis, phosphorylation, kinase activity |
HUMMLC2B | - | 16p11.2 | calcium ion binding, muscle myosin |
MELK | + | 9p13.2 | ATP binding, phosphorylation, tyrosine kinase activity |
PPARA | - | 22q12-q13.1 | Transcription factor, steroid hormone activity/lipid metabolism |
DHCR7 | + | 11q13.2-q13.5 | cholesterol binding and biosynthesis, electron transporter activity |
MAD2L1 | + | 4q27 | Cell-cycle, mitotic checkpoint, spindle |
ZWINT | + | 10q21-q22 | Nucleus |
KIF20A | + | 5q31 | ATP binding, microtubule associated complex |
CDCA8 | + | 1p34.3 | Cytokinesis |
KIAA0101 | + | 15q22.31 | PCNA associated factor |
TIMELESS | + | 12q12-q13 | Development, negative regulation of transcription |
PTTG1 | + | 5q35.1 | DNA metabolism, repair, replication and chromosome cycle |
WSB2 | + | 12q24.23 | Intracellular signaling cascade |
ABCC5 | + | 3q27 | ATP binding, ATPase activity, transmembrane movement |
KIF23 | + | 15q23 | ATP binding, microtubule complex/motor activity, mitosis |
H2AFY | + | 5q31.3-q32 | DNA binding, chromosome organization, nucleosome assembly |