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Table 3 Top prognostic genes in ER+ breast cancer

From: A consensus prognostic gene expression classifier for ER positive breast cancer

UniGene symbol Coefficient sign Cytoband GO
RACGAP1 + 12q13.12 GTPase activator activity, electron transporter activity
STK6 + 20q13.2-q13.3 ATP binding, mitosis, phosphorylation, kinase activity
HUMMLC2B - 16p11.2 calcium ion binding, muscle myosin
MELK + 9p13.2 ATP binding, phosphorylation, tyrosine kinase activity
PPARA - 22q12-q13.1 Transcription factor, steroid hormone activity/lipid metabolism
DHCR7 + 11q13.2-q13.5 cholesterol binding and biosynthesis, electron transporter activity
MAD2L1 + 4q27 Cell-cycle, mitotic checkpoint, spindle
ZWINT + 10q21-q22 Nucleus
KIF20A + 5q31 ATP binding, microtubule associated complex
CDCA8 + 1p34.3 Cytokinesis
KIAA0101 + 15q22.31 PCNA associated factor
TIMELESS + 12q12-q13 Development, negative regulation of transcription
PTTG1 + 5q35.1 DNA metabolism, repair, replication and chromosome cycle
WSB2 + 12q24.23 Intracellular signaling cascade
ABCC5 + 3q27 ATP binding, ATPase activity, transmembrane movement
KIF23 + 15q23 ATP binding, microtubule complex/motor activity, mitosis
H2AFY + 5q31.3-q32 DNA binding, chromosome organization, nucleosome assembly
  1. Top ranked 17 prognostic genes in ER+ breast cancer as determined by a meta-analysis of three major breast cancer data sets. We give the sign of their global average Cox-regression coefficient ('+' means upregulated in poor outcome tumors; '-' means downregulated in poor outcome tumors), cytoband position and selected abbreviated Gene Ontology.