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Table 2 The D-index of prognostic factors across cohorts

From: A consensus prognostic gene expression classifier for ER positive breast cancer

 

Training

Test

Factor

NKI2

ECM

NCH

JRH-1

UPP

JRH-2*

Grade

3.80 (<10-5)

NA

3.57 (0.001)

3.84 (0.003)

2.55 (0.0003)

2.15 (0.17)

Node status

1.01 (0.97)

all LN-

2.23 (0.05)

2.64 (0.04)

4.03 (<10-6)

2.36 (0.25)

Size

1.59 (0.06)

NA

3.36 (0.003)

4.16 (<10-3)

3.18 (<10-5)

3.04 (0.008)

NPI

2.27 (<10-3)

NA

4.07 (<10-3)

5.16 (<10-4)

3.82 (<10-7)

3.78 (0.03)

MPI†

3.32 (<10-3)

2.29 (0.002)

NA

3.20 (0.002)

2.71 (<10-4)

7.96 (<10-4)

MPI‡

3.64 (<10-7)

2.56 (<10-6)

6.45 (<10-5)

3.44 (<10-3)

2.80 (<10-4)

11.26 (<10-5)

MPI§

3.64 (<10-6)

2.51 (<10-5)

6.51 (<10-5)

3.10 (<10-5)

2.84 (0.001)

10.10 (<10-4)

  1. For the classical prognostic factors we give, where available, the D-index and log-rank test p values in the training cohorts NKI2, ECM and NCH, and test cohorts JRH-1, UPP and JRH-2. *For JRH-2 the number of samples with available grade and node status information were only 57 and 38, respectively. †For the MPI we give the median D-index and log-rank test p value over the ten molecular classifiers. The range for the D-index and p values over the 10 classifiers were: 2.27 to 4.35 (0.009 to 1.1 × 10-5) in NKI2; 1.78 to 2.75 (0.024 to 2 × 10-4) in ECM; 2.04 to 3.96 (0.039 to 0.0003) in JRH-1; 2.39 to 3.04 (1.7 × 10-4 to 6.7 × 10-6) in UPP; and 5.08 to 12.61 (8 × 10-4 to 8.4 × 10-6) in JRH-2. ‡The MPI based on the optimal 52-gene classifier. §The MPI based on the 17-gene classifier. NA, not available.
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Genome Biology

ISSN: 1474-760X

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