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Table 2 The D-index of prognostic factors across cohorts

From: A consensus prognostic gene expression classifier for ER positive breast cancer

  Training Test
Factor NKI2 ECM NCH JRH-1 UPP JRH-2*
Grade 3.80 (<10-5) NA 3.57 (0.001) 3.84 (0.003) 2.55 (0.0003) 2.15 (0.17)
Node status 1.01 (0.97) all LN- 2.23 (0.05) 2.64 (0.04) 4.03 (<10-6) 2.36 (0.25)
Size 1.59 (0.06) NA 3.36 (0.003) 4.16 (<10-3) 3.18 (<10-5) 3.04 (0.008)
NPI 2.27 (<10-3) NA 4.07 (<10-3) 5.16 (<10-4) 3.82 (<10-7) 3.78 (0.03)
MPI 3.32 (<10-3) 2.29 (0.002) NA 3.20 (0.002) 2.71 (<10-4) 7.96 (<10-4)
MPI 3.64 (<10-7) 2.56 (<10-6) 6.45 (<10-5) 3.44 (<10-3) 2.80 (<10-4) 11.26 (<10-5)
MPI§ 3.64 (<10-6) 2.51 (<10-5) 6.51 (<10-5) 3.10 (<10-5) 2.84 (0.001) 10.10 (<10-4)
  1. For the classical prognostic factors we give, where available, the D-index and log-rank test p values in the training cohorts NKI2, ECM and NCH, and test cohorts JRH-1, UPP and JRH-2. *For JRH-2 the number of samples with available grade and node status information were only 57 and 38, respectively. For the MPI we give the median D-index and log-rank test p value over the ten molecular classifiers. The range for the D-index and p values over the 10 classifiers were: 2.27 to 4.35 (0.009 to 1.1 × 10-5) in NKI2; 1.78 to 2.75 (0.024 to 2 × 10-4) in ECM; 2.04 to 3.96 (0.039 to 0.0003) in JRH-1; 2.39 to 3.04 (1.7 × 10-4 to 6.7 × 10-6) in UPP; and 5.08 to 12.61 (8 × 10-4 to 8.4 × 10-6) in JRH-2. The MPI based on the optimal 52-gene classifier. §The MPI based on the 17-gene classifier. NA, not available.