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Figure 1 | Genome Biology

Figure 1

From: A consensus prognostic gene expression classifier for ER positive breast cancer

Figure 1

(a) For each of 10 random partitions of training cohorts into training and test sets we rank the genes according to their average Cox-scores over the N train training cohorts (N train = 3). (b) 1, Definition of MPI and evaluation of the optimal classifier(s) using the independent test sets of the training cohorts. 2, D p s ( n ) MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2Caerbhv2BYDwAHbqedmvETj2BSbqee0evGueE0jxyaibaiKI8=vI8tuQ8FMI8Gi=hEeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciGacaGaaeqabaqadeqadaaakeaacaWGebWaa0baaSqaaiaadchacaWGZbaabaGaaiikaiaad6gacaGGPaaaaaaa@385C@ denotes the D-index of the top n-gene classifier for partition/realization p in test set of the training cohort s. 3, D p ( n ) MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2Caerbhv2BYDwAHbqedmvETj2BSbqee0evGueE0jxyaibaiKI8=vI8tuQ8FMI8Gi=hEeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciGacaGaaeqabaqadeqadaaakeaacaWGebWaa0baaSqaaiaadchaaeaacaGGOaGaamOBaiaacMcaaaaaaa@3764@ denotes the weighted average D-index over the test sets in the training cohorts where N s denotes the size of the test set of training cohort s. 4, The optimal classifier for each partition/realization p, M P I p MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2Caerbhv2BYDwAHbqedmvETj2BSbqee0evGueE0jxyaibaiKI8=vI8tuQ8FMI8Gi=hEeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciGacaGaaeqabaqadeqadaaakeaacaWGnbGaamiuaiaadMeadaqhaaWcbaGaamiCaaqaaiabgEHiQaaaaaa@37B3@ , is defined by the number of top-ranked genes, n, that maximizes D p ( n ) MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2Caerbhv2BYDwAHbqedmvETj2BSbqee0evGueE0jxyaibaiKI8=vI8tuQ8FMI8Gi=hEeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciGacaGaaeqabaqadeqadaaakeaacaWGebWaa0baaSqaaiaadchaaeaacaGGOaGaamOBaiaacMcaaaaaaa@3764@ . (c) Validation of the optimal classifiers M P I p MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2Caerbhv2BYDwAHbqedmvETj2BSbqee0evGueE0jxyaibaiKI8=vI8tuQ8FMI8Gi=hEeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciGacaGaaeqabaqadeqadaaakeaacaWGnbGaamiuaiaadMeadaqhaaWcbaGaamiCaaqaaiabgEHiQaaaaaa@37B3@ in completely independent external cohorts.

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