Loss of LIN-35, the Caenorhabditis elegansortholog of the tumor suppressor p105Rb, results in enhanced RNA interference

Table 2 RNAi induced silencing of lin-35 or lin-15B enhances the dsRNA-induced silencing of a GFP transgene

RNAi*	Complete^†	GFP expression partial^‡	None^§	% Complete expression
control	44	15	23	54%
lin-35	1	25	75	1%
lin-15B	1	16	78	1%
eri-1	7	16	30	13%
rde-4	28	6	8	67%

*RNAi experiments were performed as described in Materials and methods. ^†Number of worms with GFP expression in all hypodermal seam cells. ^‡Number of worms with GFP expression only in their anterior and/or posterior seam cells, but not in the midbody seam cells. ^§Number of worms with no GFP expression visible in any cells.

ISSN: 1474-760X