TY - JOUR AU - Lehner, Ben AU - Calixto, Andrea AU - Crombie, Catriona AU - Tischler, Julia AU - Fortunato, Angelo AU - Chalfie, Martin AU - Fraser, Andrew G. PY - 2006 DA - 2006/01/20 TI - Loss of LIN-35, the Caenorhabditis elegansortholog of the tumor suppressor p105Rb, results in enhanced RNA interference JO - Genome Biology SP - R4 VL - 7 IS - 1 AB - Genome-wide RNA interference (RNAi) screening is a very powerful tool for analyzing gene function in vivo in Caenorhabditis elegans. The effectiveness of RNAi varies from gene to gene, however, and neuronally expressed genes are largely refractive to RNAi in wild-type worms. SN - 1474-760X UR - https://doi.org/10.1186/gb-2006-7-1-r4 DO - 10.1186/gb-2006-7-1-r4 ID - Lehner2006 ER -