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Figure 6 | Genome Biology

Figure 6

From: Challenging the spliceosome machine

Figure 6

Individual information spread is sensitive to neighborhood constraints. Individual information was computed at nucleotide positions -8 to +12 of donor sites flanking introns with lengths 1,024 to 4,095 based on a reference set of introns with lengths 8,192 to 16,383. For each computation, the neighborhood introns or exons were either constrained (red) or not constrained (blue) as illustrated in the figure. The various datasets used were as follows. (a) Introns with lengths 1,024 to 4,095 flanked by introns with lengths 64 to 127 (red); mean individual information = 9.18 ± 2.30 (n = 55). (b) Introns with lengths 1,024 to 4,095 flanked by introns with lengths >175 (red); mean individual information = 9.56 ± 3.17 (n = 311). (c) Introns with lengths 1,024 to 4,095 flanked by exons with lengths >190 (red); mean individual information = 8.91 ± 3.07 (n = 681). (For comparison, the mean individual information of all introns with lengths 1,024 to 4,095 (blue) is 8.75 ± 3.35 (n = 2,128).)

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