Table 1 Host drug targets that have antiviral activity
Virus family | Virus species | Host-cell target | Drug | Antiviral activity in vitro | Antiviral activity in vivo | References |
|---|---|---|---|---|---|---|
Poxviridae | Vaccinia virus | Abl tyrosine kinase | Gleevec | + | + | [13] |
Herpesviridae | KSHV | c-Kit | Gleevec | + | + | [14,21] |
| Â | KSHV | Vitamin D receptor | Vitamin D analog EB1089 | + | - | [16] |
|  | HSV-1 | EIF-2α | Salubrinal | + | - | [30] |
| Â | HCMV | COX-2 | BMS-279652 | + | - | [15,23] |
| Â | Â | Â | BMS-279654 | Â | Â | Â |
| Â | Â | Â | BMS-279655 | Â | Â | Â |
| Â | Â | Â | Indomethacin | Â | Â | Â |
| Â | Â | Â | Aspirin | Â | Â | Â |
Unclassified | Hepatitis D virus | Farnesyltransferase | FTI-277 | + | + | [18,19] |
| Â | Â | Â | FTI-2153 | Â | Â | Â |
Hepadnaviridae | Hepatitis B virus | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) | siRNA | + | - | [31] |
Retroviridae | HIV | HMG-CoA reductase | Lovastatin | + | + | [17] |
| Â | HIV | Geranylgeranyltransferase I | GGTI-286 | + | - | [17] |
| Â | HIV | ATM kinase | KU-55933 | + | - | [28] |
| Â | HIV | Deoxyhypusine synthase | CNI-1493 | + | - | [29] |
| Â | HIV | Histone deacetylase | Valporic acid | + | + | [32,33] |
Flaviviridae | West Nile disease virus | c-Yes (Src family kinases) | PP2 SU6656 | + | - | [20] |