Figure 1

Gene expression programs in the human eye. Unsupervised hierarchical clustering of 38 samples from human cadaver eyes and normal brain. Array elements that varied at least 2.5-fold from the median on at least two microarrays were included (9,634 cDNA elements representing approximately 6,600 genes). (a) Array dendrogram. G1 to G8 indicate the globes from which each compartment sample was dissected (see Materials and methods). Inf., inferior; Sup., superior; Temp., temporal. (b) Cluster image. Data are displayed as a hierarchical cluster where rows represent genes (unique cDNA elements) and columns represent experimental samples. Colored pixels capture the magnitude of the response for any gene, where shades of red and green represent induction and repression, respectively, relative to the median for each gene. Black pixels reflect no change from the median and gray pixels represent missing data. Compartment-specific gene signatures are indicated. See our website for a searchable version of this cluster [75].