Canonical Wnt signaling: high-throughput RNAi widens the path

Table 1 Principal components of the Wingless signaling pathway in Drosophila and their human orthologs

There is greater redundancy of Wnt pathway components in humans than in Drosophila. In addition to Wingless and Frizzled2, there are six other Wnt proteins in Drosophila and three other Frizzled family members. In contrast, humans have 16 Wnts and 10 Frizzleds. There are two APC paralogs in both species, but other components downstream of Frizzled in Drosophila are unique. APC, the adenomatous polyposis coli protein; GSK3, glycogen synthase kinase 3; Zw3, zeste-white 3.

ISSN: 1474-760X