Figure 2From: The Dictyostelium genome encodes numerous RasGEFs with multiple biological rolesPhylogenetic analysis of predicted Dictyostelium RasGEFs. The RasGEF domains of (a) the predicted Dictyostelium RasGEFs alone or (b) the predicted Dictyostelium RasGEFs with selected representatives of human RasGEF families were aligned using ClustalX 1.83. Domain boundaries were predicted by SMART [34]. Phylogenetic trees were constructed using 1,000 bootstraps, excluding all matches within gaps. Closed circles indicate nodes found in 100% of bootstraps; open circles indicate nodes found in ≥50% of bootstraps. All other nodes are found in <50% of bootstraps.Back to article page