Figure 1

From networks to biology. (a) A network representation of a human protein-protein interaction map that we generated by integrating all of the available high-confidence protein interactions from model organism high-throughput protein interaction datasets http://www.sanger.ac.uk/interactionmap and visualised using the LGL tool http://bioinformatics.icmb.utexas.edu/lgl/. Most nodes (proteins) are connected in one large network (centre), but some are connected in small groups or pairs (outer areas). (b) A three-dimensional model of the Golgi region of a pancreatic cell line, as reconstructed by electron tomography. The seven cisternae that comprise the Golgi in the region are false-colored light blue, pink, cherry red, green, dark blue, gold and bright red, respectively. The endoplasmic reticulum is yellow, membrane-bound ribosomes are blue, free ribosomes are orange, microtubules are bright green, dense core vesicles are bright blue, clathrin-negative vesicles are white, clathrin-positive compartments and vesicles are bright red, clathrin-negative compartments and vesicles are purple, and mitochondria are dark green. The scale bar represents 500 nm. Reproduced with permission from Marsh BJ, et al., Proc Natl Acad Sci USA 2001, 98:2399-2406.