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Table 2 Properties of some human SET-domain proteins

From: The SET-domain protein superfamily: protein lysine methyltransferases

  Chromosomal location Gene size (kb) Number of coding exons Protein size (amino acids) Domains common to the family in addition to the SET domain Domains unique to particular members GenBank accession number
SUV39 family      Pre-SET (9 Cys, 3 Zn), post-SET (CXCX4C)   
SUV39H1 Xp11.23 12.4 6 412   4 Cys, chromo 4507321
SUV39H2 10p13 24 6 477 (Mm)*   4 Cys, chromo 9956936
G9a 6p21.33 17.3 28 1,210   E/KR-rich, NRSF-binding, ankyrin repeats 18375637
GLP1 (EuHMT1) 9q34.3 120 25 1,267   Same as G9a 20372683
ESET (SETDB1) 1q21.2 37 21 1,291   Tudor, MBD 505110
CLLL8 (SETDB2) 13q14.2 40 14 719   MBD 13994282
SET1 family      Post-SET (CXCX4C)   
MLL1 (HRX, ALL1) 11q23.3 86 36 3,969   AT hook, Bromo PHD, CXXC 1170364
HRX2 (MLL4) 19q13.12 20 37 2,715   Same as above 12643900
ALR (MLL2) 12q13.12 34 54 5,262   PHD, ring finger 2358285
MLL3 7q36.1 299 58 4,911   PHD, ring finger 21427632
SET1 (ASH2) 16p11.2 26 18 1,707   RRM, poly-S/E/P 6683126
SET1L 12q24.31 14 11 1,092 (Mm)*   RRM, poly-S/E/P 23468263
SET2 family      Pre-SET (7-9 Cys); post-SET (CXCX4C)   
WHSC1 (NSD2) 4q16.3 79 21 1,365   PWWP, PHD, HMG, ring finger 6683809
WHSCL1 (NSD3) 8p12 73 23 1,437   PWWP, PHD, ring finger 13699811
NSD1 5q35.3 160 23 2,696   PWWP, PHD, ring finger 19923586
HIF1 (HYPB) 3p21.31 106 19 2,061   WW 12697196
ASH1 1q22 184 27 2,969   AT hook, bromo, BAH, PHD 7739725
RIZ family        
RIZ (PRDM2) 1p36.21 86 9 1,719   C2H2 zinc finger 9955379
BLIMP1 (PRDM1) 6q21 19 6 789   C2H2 zinc finger 3493158
SMYD family      Post-SET (CXCX2C)   
SMYD3 1q44 758 12 428   Zf-MYND 30913569
SMYD1 2p11.2 43 9 490   Zf-MYND 38093643
EZ family      Pre-SET (~15 Cys)   
EZH1 17q21.2 26 19 747   2 SANT 3334182
EZH2 7q36.1 40 19 746   2 SANT 3334180
SUV4-20 family      Post-SET (CXCX2C)   
SUV4-20H1 11q13.2 57 9 876    50659081
SUV4-20H2 19q13.42 8 8 462    31543168
Others        
SET7/9 4q31.1 45 8 366   MORN 25091213
SET8 (PR-SET7) 12q24.31 26 8 393    25091219
  1. The seven families of SET-domain proteins are classified according to the sequences surrounding their SET domain. *Complete human SUV39H2 and SET1L cDNAs are not available in current databases, but partial cDNA and genomic sequences corresponding to the mouse sequences (Mm) are present. For the pre-SET and post-SET domains, the number and (if known) the arrangement of cysteines in the domain is given. Domain abbreviations and definitions: ankyrin repeats, tandemly repeated modules of about 33 amino acids; AT hook, DNA binding motif with a preference for A/T-rich regions; BAH, Bromo adjacent homology domain; bromo, bromodomain, which can interact specifically with acetylated lysines; chromo, chromatin organization modifier domain; CXXC, domain with two cysteines separated by two amino acids; E/KR-rich, glutamine- or lysine/arginine-rich domains; HMG, high mobility group domain; MBD, methyl-binding domain; MORN, membrane occupation and recognition nexus repeat; NRSF-binding, binds neuron-restrictive silencing factor/repressor element 1 silencing transcription factor; PHD, folds into an interleaved type of Zn-finger chelating two Zn ions; poly-S/E/P, runs of serine, glutamate or proline; PWWP, domain including a conserved Pro-Trp-Trp-Pro motif; RRM, RNA recognition motif; SANT, DNA-binding domain that specifically recognizes the sequence YAAC(G/T)G; Tudor, domain of unknown function present in several RNA-binding proteins; WW, contains two highly conserved tryptophans and binds proline-rich peptide motifs; Zf-MYND, 'myeloid, Nervy, DEAF-1' domain consisting of a cluster of cysteine and histidine residues.
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