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Table 3 Genes binding Hsf in both Drosophila and S. cerevisiae

From: Genomic analysis of heat-shock factor targets in Drosophila

FlyBase

Fly ratio

Yeast

Yeast express

NO-HS

HS

Lee ratio

Lee p

BLAST

Yeast GO function

Acon

0.968

ACO1

2.876

0.833

0.516

1.86

6.90E-02

4.00E-274

Aconitate hydratase

Hsc70-5

1.686

SSC1

1.98

0.999

0.999

7.05

1.50E-04

6.60E-201

Protein transporter*

Hsp60

1.039

HSP60

2.608

0.997

0.997

2.33

1.50E-02

1.00E-177

Single-stranded DNA binding*

Cctgamma

1.275

CCT3

-0.28

0.646

0.343

1.85

7.80E-02

4.00E-162

Unfolded protein binding*

l(1)G0022

1.591

CCT6

0.063

0.714

0.921

1.73

8.60E-02

1.00E-136

Unfolded protein binding*

Hsc70Cb

2.164

SSE1

1.771

0.998

0.999

4.48

1.50E-03

1.70E-115

Unfolded protein binding*

CG8863

0.818

YDJ1

1.529

0.999

0.997

6.62

2.40E-04

2.00E-74

Chaperone regulator*

Cyp1

1.805

CPR1

1.251

0.996

0.995

10.83

3.40E-05

3.00E-65

Peptidyl-prolyl cis-trans isomerase

CG8258

1.962

CCT4

NA

0.385

0.055

1.85

7.80E-02

3.00E-55

Unfolded protein binding*

CG2918

1.100

SSA3

4.479

0.934

0.995

1.19

4.80E-01

7.00E-50

ATPase

DnaJ-1

2.375

SIS1

3.237

0.999

0.999

11.31

3.50E-05

7.00E-46

Unfolded protein binding*

Rab35

1.416

YPT32

0.338

0.269

0.343

1.98

4.30E-02

4.00E-40

GTPase activity

sktl

1.462

MSS4

1.042

0.712

0.879

1.91

4.80E-02

7.00E-35

Phosphatidylinositol kinase

CG4800

1.424

RBF18

0.03

0.872

0.964

2.13

1.50E-01

1.00E-33

Unknown

Cyt-c-d

0.932

CYC1

1.738

0.959

0.942

2.53

1.10E-02

4.70E-33

Electron carrier

mbf1

0.706

MBF1

NA

0.999

0.998

9.4

1.80E-04

2.00E-29

Transcription coactivator

CG1416

2.793

AHA1

3.288

0.999

0.999

9.14

5.60E-04

3.00E-28

Chaperone activator*

CG4500

1.37

FAA1

3.889

0.796

0.943

2.61

8.00E-03

9.00E-23

Fatty-acid-CoA ligase

CG32920

1.081

AHP1

1.547

0.983

0.984

3.81

1.10E-03

1.10E-19

Thioredoxin peroxidase

SH3PX1

0.877

SNX4

1.26

0.824

0.372

2.52

1.30E-02

6.30E-13

lipid binding

CG10973

1.532

FES1

3.541

0.997

0.993

NA

NA

1.10E-10

Adenyl-nucleotide exchange factor

l(2)35Bg

0.755

DRE2

0.304

0.843

0.832

3.36

3.70E-03

5.00E-10

Unknown

CG12200

0.786

CST9

1.022

0.346

0.467

1.69

9.40E-02

8.70E-10

DNA binding

  1. The FlyBase gene ID is given, along with the average asinh ratio of Hsf enrichment. Yeast homologs are indicated by their Saccharomyces genome database (SGD) common names. The average heat-induced expression and ranking of Hsf binding in non-heat shocked (NO-HS) and heat shocked (HS) cells are from [28], the Lee ratio and Lee p are from [27]. BLAST scores are derived from searches at the SGD using the Drosophila sequences as probes. Gene Ontology (GO) functional classifications are for the yeast proteins; asterisks indicate stress-response proteins.
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Genome Biology

ISSN: 1474-760X

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