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Table 2 Top-ranking knock-out experiments proposed for model discrimination

From: Validation and refinement of gene-regulatory pathways on a network of physical interactions

Gene Function Score Downstream genes Rank Model
HHF1 Histone 52.1429 74 1 2
SOK2* Regulator for meiosis and PKA pathway 45.0279 64 2 1
CKA1 Protein kinase of cell cycle 45.0075 64 3 5
A2 Mating response 40.9023 58 4 4
YAP6* Stress response regulator 35.1652 50 5 1, 3
NRG1 Regulator of glucose dependent genes 31.6501 45 6 3
FKH1 Regulator of cell cycle 29.1194 41 7 2
FKH2 Regulator of cell cycle 26.7131 38 8 7
SLT2 Protein kinase of cell wall integrity pathway 23.4727 31 9 8
MSN4* Regulator of stress response 21.8224 31 10 1
HAP4* Regulator of cellular respiration 6.3310 9 34 1
  1. Each proposed target gene is reported, along with its function, mutual information score, rank, and the model(s) it informs. All target genes are non-lethal in rich media. *Gene knockouts selected in this study.