From: Validation and refinement of gene-regulatory pathways on a network of physical interactions
Model | Number of genes | Number of variants | Validated literature pathway | Enriched MIPS functions |
---|---|---|---|---|
0 | 130 | 1 | Kss1/Fus3-Ste12 (mating response and filamentous growth) | Cell fate (1.48 × 10-7); metabolism (0.0067) |
1 | 69 | 8 | Sok2-Msn4 (PKA pathway) | Â |
2 | 63 | 16 | Tup1-Hhf1 (histone regulation) | Protein synthesis (7.13 × 10-8) |
3 | 44 | 2 | Tup1/Ssn6-Nrg1 (glucose metabolism) | Transport (1.05 x 10.5); metabolism (5.41 × 10-4) |
4 | 58 | 8 | Tup1/Ssn6-α2/Mcm1 (mating response) | Cell fate (1.12 × 10-5); |
5 | 58 | 4 | Rpd3-Abf1 (histone modification) | Â |
6 | 44 | 2 | Swi4-Ndd1-Ace2 (cell cycle) | Â |
7 | 26 | 4 | Â | Cell cycle (0.035) |
8 | 36 | 8 | Slt2-Rlm1/Swi4 (PKC pathway) | Â |
10 | 45 | 16 | Med2-Gal4/Gcn4 (general transcription) | Â |
15 | 13 | 4 | Cmd1-Cna1-Skn7 (calcium signaling) | Â |
19 | 9 | 4 |  | Cell defense (6.33 × 10-6) |
23 | 17 | 2 |  | Metabolism (1.49 × 10-6);energy (0.04) |
26 | 8 | 8 |  | Cell defense (9.62 × 10-5) |
29 | 9 | 4 | Yap1-Cad1 (metal response) | Â |
30 | 12 | 4 | Med2-Srb6-Gal4 (general transcription) | Â |
32 | 12 | 4 | Med2-Gal11-Gal4 (general transcription) | Â |
33 | 12 | 4 | Med2-Srb5-Gal4 (general transcription) | Â |
34 | 9 | 4 | Ste12-Mcm1 (mating response) | Cell fate (4.55 × 10-8); homeostasis (0.0012); cell communication (0.0345) |
36 | 7 | 4 | Â | Metabolism (0.0258) |
40 | 5 | 2 | Â | Metabolism (0.0017) |