Simulated learning curves of three experimental design methods. Three different methods of selecting experiments are compared: mutual information scores (triangles), hub selection (circles), and random selection (squares). We performed 100 simulated trials and show the average number of ambiguous interactions remaining in the inferred model after each simulated knockout experiment. Vertical bars indicate the standard deviations for the random selection method. The standard deviations for the information and hub selection curves are less than five and are not shown for clarity.