Creation and disruption of protein features by alternative splicing - a novel mechanism to modulate function

Table 1 RefSeq transcripts where, due to alternative splicing, sequence insertion destroys a TM helix

Gene symbol	Gene name	RefSeq with TM*	RefSeq/EST without TM^†	Alternative splice event^‡	Impact
DIABLO	Diablo homolog (Drosophila)	NM_138929	NM_019887	Exon between exon 2 and 3	Disruption of the single TM domain, soluble protein
DPP8	Dipeptidylpeptidase 8	NM_017743	NM_197961	Exon between exon 15 and 16	Disruption of the single TM domain, soluble protein
COX7A2	Cytochrome c oxidase subunit VIIa polypeptide 2 (liver)	NM_001865	BU570379	Donor downstream of exon 3	Disruption of the single TM domain, soluble protein
RHCE	Rhesus blood group, CcEe antigens	NM_138617	NM_138618	Two exons between exon 3 and 4	Disruption of the fifth TM domain, insert contains three new TM domains
na	na	NM_014738	BM693684	Intron between exon 30 and 31	Disruption of the eighth TM domain
na	na	NM_152672	CF147426	Acceptor upstream of exon 4	Disruption of the second TM domain

*RefSeq transcript without the insert (shorter variant) that encodes a TM domain. ^†Transcript with the insert (longer variant) that destroys a TM helix. ^‡Exon numbers refer to the RefSeq transcript with the TM helix. na, not approved; TM, transmembrane.

ISSN: 1474-760X