Figure 1

TM domain destruction by exon insertion. (a) Exons 2 and 3 of NM_138929 of DIABLO encode a TM domain (shown as blue boxes). This TM domain is destroyed in another transcript (NM_019887) that includes an additional exon. The inserted exon (shown in red) encodes many polar amino acids. (b) Exons 3 and 4 of NM_138617 of RHCE encode a TM domain that is destroyed in NM_138618 by the inclusion of two exons. Interestingly, the two included exons encode three new TM domains. Thus, the skipping of exon 4 and 5 of NM_138618 results in a protein that has only two instead of three TM domains fewer. Exon numbers refer to the respective transcript. TM, transmembrane.