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Table 1 DNA sequence and expression divergence of human and chimpanzee promoters

From: Functional analysis of human and chimpanzee promoters

Promoter Divergence Divergence TSS Brain§ Liver§ Neuroblastoma Cervical carcinoma
ACADSB 1.4 3.3 -1.6 -1.3 -0.5* -0.3*
C10orf10 1.3 1.8 ND 4.0 1.4** 0.7***
CGI-51 1.6 1.9 -0.4 -1.3 0.3* 0.1
DDX17 1.8 2.0 -4.2 -4.4 0 -0.1
DHX16 1.5 0.9 -0.8 -1.7 0 0.1
HLA-DPB1 0.8 0.9 2.5 4.1 0.2 0.2
IMPA1 1.5 2.6 2.3 2.6 0.6* 0.2
PCOLCE 0.9 0.6 ND 2.1 0 0.2
SH3BGR 1.6 1.3 1.9 2.4 -0.8 -0.7***
TERF1 1.5 1.4 2.3 1.6 -0.7* 0
THEM2 1.2 2.6 -0.5 -0.8 0.1 0.1
UNG 0.6 0.5 2.5 1.8 -0.3* 0
  1. Point substitutions per compared site in the whole promoter (~ 2 kbp); point substitutions per compared site around the transcription start site (-200 to +20); §signal log2 ratio as determined from arrays, where positive values indicate higher expression in humans (that is, a value of 1 means twofold higher expression in humans); average signal log2 ratio for the promoter activity in cell lines; *, ** and *** indicate p-values (ANOVA) < 0.05, 0.01, and 0.001, respectively.