Functional analysis of human and chimpanzee promoters

Table 1 DNA sequence and expression divergence of human and chimpanzee promoters

Promoter	Divergence^†	Divergence TSS^‡	Brain^§	Liver^§	Neuroblastoma^¶	Cervical carcinoma^¶
ACADSB	1.4	3.3	-1.6	-1.3	-0.5*	-0.3*
C10orf10	1.3	1.8	ND	4.0	1.4**	0.7***
CGI-51	1.6	1.9	-0.4	-1.3	0.3*	0.1
DDX17	1.8	2.0	-4.2	-4.4	0	-0.1
DHX16	1.5	0.9	-0.8	-1.7	0	0.1
HLA-DPB1	0.8	0.9	2.5	4.1	0.2	0.2
IMPA1	1.5	2.6	2.3	2.6	0.6*	0.2
PCOLCE	0.9	0.6	ND	2.1	0	0.2
SH3BGR	1.6	1.3	1.9	2.4	-0.8	-0.7***
TERF1	1.5	1.4	2.3	1.6	-0.7*	0
THEM2	1.2	2.6	-0.5	-0.8	0.1	0.1
UNG	0.6	0.5	2.5	1.8	-0.3*	0

^†Point substitutions per compared site in the whole promoter (~ 2 kbp); ^‡point substitutions per compared site around the transcription start site (-200 to +20); ^§signal log₂ ratio as determined from arrays, where positive values indicate higher expression in humans (that is, a value of 1 means twofold higher expression in humans); ^¶average signal log₂ ratio for the promoter activity in cell lines; *, ** and *** indicate p-values (ANOVA) < 0.05, 0.01, and 0.001, respectively.

ISSN: 1474-760X