From: Refinement and prediction of protein prenylation motifs
 | FT | GGT1 | ||||
---|---|---|---|---|---|---|
 | Prosite PS00294 | Beese, Casey and colleagues' rules | PrePS FT | Prosite PS00294 | Beese, Casey and colleagues' rules | PrePS GGT1 |
Sensitivity I | 85%* | 72% | 100% | 95%* | 67% | 100% |
Sensitivity II | NA | NA | 92.6/97.9% †| NA | NA | 98.6% |
Probability of false positive prediction (POFP) for -CXXX motifs (GenBank sequences) | 17.1%* | 9.9% | 6.3% | 17.1%* | 10.0% | 1.2% |
POFP -CXXX 'cytoplasmic'‡ | 18.2%* | 8.9% | 5.1% | 18.2%* | 8.6% | 1.4% |
POFP -CXXX 'nuclear'‡ | 13.9%* | 10.5% | 5.5% | 13.9%* | 9.6% | 1.1% |
POFP -CXXX 'membrane'‡ | 17.5%* | 10.3% | 3.8% | 17.5%* | 12.0% | 0.8% |
POFP --CXXX 'extracellular'$ | 8.6%* | 7.9% | 3.3% | 8.6%* | 9.0% | 0.2% |
Overall probability of false positive prediction (GenBank sequences, assuming 1.7% with -CXXX) | 0.29%* | 0.16% | 0.11% | 0.29%* | 0.17% | 0.02% |